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Oncostatin M信息

英文名称:Oncostatin M
中文名称:肿瘤抑制因子
靶点别称:OSM
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

Oncostatin M产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
OSM-H5213
Human
ActiveMax® Human Oncostatin M (OSM) Protein, Tag Free

Oncostatin M 分子别名

OSM,MGC20461,Oncostatin M

Oncostatin M 分子背景

Oncostatin M is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR. Oncostatin M (OSM) was previoustly identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6 and G-CSF, has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degree but is not stable at 90 degrees. The three dimensional structure of human OSM has been solved to atomic resolution, confirming the predicted long chain four helix bundle topology. Comparing this structure with the known structures of other known LC cytokines shows it to be most closely related to LIF.

Oncostatin M 参考文献

Oncostatin M临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
KPL-716 (Biogen) KPL-716 临床二期 百健, kiniksa pharmaceuticals 瘙痒, 结节性痒疹, 特应性皮炎 详情
GSK-315234 GSK-315234; GSK-315234A 临床二期 葛兰素史克 类风湿性关节炎
GSK-2330811 GSK-2330811,GSK2330811; GSK 2330811 临床二期 葛兰素史克 硬皮病, 系统性硬化症 详情

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