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LIF信息

英文名称:Leukemia inhibitory factor
中文名称:白血病抑制因子
靶点别称:LIF Interleukin 6 Family Cytokine,D factor,Emfilermin,LIF,Differentiation-stimulating factor,LIF, Interleukin 6 Family Cytokine,Differentiation Inhibitory Activity,Cholinergic Differentiation Factor,Hepatocyte-Stimulating Factor III,Differentiation-Inducing Factor,Melanoma-Derived LPL Inhibitor,Human Interleukin In DA Cells,Leukemia Inhibitory Factor,HILDA,MLPLI,CDF,DIA
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

LIF产品列表

ACRO质量管理体系
 
评论(1)
LIF-H521b|Human LIF Protein, premium grade
  1. 135XXXXXXX8
  2. 2人赞
  3. 购买该蛋白主要作为包被抗原使用,用于间接ELISA的筛选工作,同时也会作为一种刺激因子,刺激不同细胞系用流式去检测,效果不错
  4. >
  5. 2021-12-28
 

LIF分子别名

LIF,CDF,DIA,HILDA,MLPLI

LIF分子背景

Leukemia inhibitory factor, or LIF, an interleukin 6 class cytokine, is a protein in cells that affects cell growth and development.Leukemia Inhibitory Factor has several functions such as cholinergic neuron differentiation, control of stem cell pluripotency, bone & fat metabolism, mitogenesis of factor dependent cell lines & promotion of megakaryocyte production in vivo.
Removal of LIF pushes stem cells toward differentiation, but they retain their proliferative potential or pluripotency. Therefore LIF is used in mouse embryonic stem cell culture. It is necessary to maintain the stem cells in an undifferentiated state, however genetic manipulation of embryonic stem cells allows for LIF independent growth, notably overexpression of the gene Nanog. LIF is not required for culture of human embryonic stem cells.

LIF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
MSC-1 MSC-1 临床一期 Northern Biologics Inc 卵巢癌, 实体瘤, 胰腺癌, 非小细胞肺癌 详情
Falbikitug AZD-0171 临床二期 阿斯利康 实体瘤 详情

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