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IL-23R产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
ILR-M5251
Mouse
Mouse IL-23 R Protein, Fc Tag
ILR-H52H4
Human
Human IL-23 R Protein, His Tag (SPR verified)
ILR-H5254
Human
Human IL-23 R Protein, Fc Tag
ILR-H82F3
Human
Biotinylated Human IL-23 R Protein, Fc,Avitag
 
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IL-23R Molecule Synonym Name

IL-23 R,IL-23 Receptor

IL-23R 分子背景

Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

IL-23R 参考文献

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