搜索
 > 【VCAM-1】重组蛋白信息

VCAM-1信息

英文名称:Vascular Cell Adhesion Molecule 1
中文名称:血管细胞粘附分子1
靶点别称:CD_antigen=CD106,L1CAM,VCAM1,V-CAM 1,INCAM-100,VCAM-1,Vascular cell adhesion protein 1
上市药物数量:1
临床药物数量:3
最高研发阶段:批准上市

VCAM-1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
VC1-H5224
Human
Human VCAM-1 / CD106 Protein, His Tag
 
评论(0)
 

VCAM-1 分子别名

VCAM1,CD106,L1CAM,INCAM-100

VCAM-1 分子背景

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

VCAM-1 参考文献

VCAM-1上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Tocopherol acetate 生育酚醋酸酯 DSE-9912 批准上市 未知 静脉血栓栓塞, 间歇性跛行, 糖尿病视网膜病变, 动脉粥样硬化事件的预防, 血栓 详情

VCAM-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
FG-4497 FG-4497,FG 4497; FG4497 临床前 FibroGen 银屑病, 关节炎
Elsibucol AGI-1096,AGI1096 临床一期 AtheroGenics, 安斯泰来 器官移植排斥
DZ-13 DZ-13; DZ13 临床一期 新南威尔士大学, 皇家阿尔弗雷德王子医院 基底细胞癌, 转移性黑色素瘤

消息提示

请输入您的联系方式,再点击提交!

确定