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IL-4信息

英文名称:Interleukin-4
中文名称:白细胞介素-4
靶点别称:B-cell stimulatory factor 1,Pitrakinra,Interleukin-4,Binetrakin,BSF-1,Lymphocyte stimulatory factor 1,IL4,IL-4
上市药物数量:0
临床药物数量:10
最高研发阶段:临床二期

IL-4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL4-H4218
Human
ActiveMax® Human IL-4 Protein, Tag Free
IL4-H82E0
Human
Biotinylated Human IL-4 Protein, Avitag,His Tag

IL-4 分子别名

IL4,BCGF1,BSF1

IL-4 分子背景

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

IL-4 参考文献

IL-4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Interleukin-4/13 Trap IL-4/IL-13 trap 临床一期 再生元制药 过敏症, 哮喘
AIR-645 AIR-645; ISIS-369645 临床二期 Ionis Pharmaceuticals, Altair Therapeutics 过敏性哮喘 详情
VAK-694 VAK-694; NVP-VAK-694 临床二期 诺华 季节性过敏性鼻炎 详情
IL-4/IL-13 trap 临床一期 再生元制药 过敏症, 哮喘
Pascolizumab SB 240683,SB240683 临床二期 葛兰素史克, PDL BioPharma 哮喘
Binetrakin (Eastman/Immunex) 临床二期 Immunex, Eastman 癌症
Dectrekumab/VAK-694 QBX-258 临床二期 诺华 继发性淋巴水肿, 哮喘 详情
Romilkimab SAR-156597; SUB-33159 临床二期 赛诺菲 特发性肺纤维化 详情
IL-4R (Aradigm) 临床二期 Aradigm 哮喘
P-45 P-45; P-45FP 临床二期 IXICO 脱发

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