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 > 【TRAIL R1】重组蛋白信息

TRAIL R1产品列表

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物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
TR1-H5228
Human
Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
TR1-H5254
Human
Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
 
评论(1)
TR1-H5254|Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
  1. 182XXXXXXX2
  2. 2人赞
  3. 购买TNFRSF10A的目的是用来测定Binding的,首先测定了一下纯度,从附件中SEC的结果也可以看出纯度还不错,有94.8%
  4. >
  5. 2019-09-30
 

TRAIL R1 分子别名

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

TRAIL R1 分子背景

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1 参考文献

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