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Semaphorin 4D信息

英文名称:Semaphorin 4D
中文名称:脑信号蛋白4D
靶点别称:CD100,C9orf164,SEMAJ,SEMA4D,BB18,GR3,A8
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Semaphorin 4D产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD0-H5257
Human
Human-SEMA4D-CD100-Protein-C-Fc-Tag
 
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Semaphorin 4D 分子别名

SEMA4D,C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4,Semaphorin-4D

Semaphorin 4D 分子背景

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

Semaphorin 4D 参考文献

Semaphorin 4D临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Pepinemab moAb VX-15/2503; VX-15; VX-15/2503 临床二期 Vaccinex, 梯瓦 亨廷顿氏舞蹈症 详情

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