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PTH1R信息

英文名称:Parathyroid hormone receptor
中文名称:甲状旁腺激素受体
靶点别称:PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone/parathyroid hormone-related peptide receptor,PTH1R,PTHR ,PTHR1,Parathyroid hormone 1 receptor,PTH1 receptor
上市药物数量:14
临床药物数量:44
最高研发阶段:批准上市

PTH1R产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
PTR-H5222
Human
Human PTH1R / PTHR1 Protein, His Tag
 
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PTH1R 分子别名

PTH1R,PTHR,PTHR1

PTH1R 分子背景

Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

PTH1R 参考文献

PTH1R上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Teriparatide biosimilar (Intas Pharmaceuticals) 特立帕肽生物类似药(Intas Pharmaceuticals) rhPTH (1-34) (Intas Pharmaceuticals) 批准上市 Intas Biopharmaceuticals 骨质疏松症
Teriparatide biosimilar (STADA Arzneimittel AG) 特立帕肽生物类似药(STADA Arzneimittel AG) rhPTH (1-34) (STADA Arzneimittel AG) 批准上市 STADA Arzneimittel teriparatide ema

Movymia is indicated in adults.

Treatment of osteoporosis in postmenopausal women and in men at increased risk of fracture. In postmenopausal women, a significant reduction in the incidence of vertebral and no

STADA Arzneimittel AG 2017-01-11 骨质疏松症
Teriparatide biosimilar (Virchow/Sun) 特立帕肽生物类似药(Virchow/Sun) rhPTH (1-34) (Virchow/Sun) 批准上市 Virchow Group, 太阳制药 骨质疏松症 详情
Teriparatide biosimilar (Gedeon Richter) 特立帕肽生物类似药(Gedeon Richter) rhPTH (1-34) (Gedeon Richter) 批准上市 吉瑞大药厂 teriparatide ema

Terrosa is indicated in adults.

Treatment of osteoporosis in postmenopausal women and in men at increased risk of fracture. In postmenopausal women, a significant reduction in the incidence of vertebral and no

Gedeon Richter Plc. 2017-01-04 骨质疏松症
Teriparatide biosimilar (USV) 特立帕肽生物类似药 (USV) 批准上市 USV 骨质疏松症
Teriparatide biosimilar (Pfenex) 特立帕肽生物类似药(Pfenex) rhPTH (1-34) (Pfenex); PF-708 批准上市 Pfenex, 泰凌医药, Alvogen BONSITY fda PFENEX INC 2019-10-04 骨质疏松症 详情
Teriparatide biosimilar (Zydus Cadila) 特立帕肽生物类似药(Zydus Cadila) rhPTH (1-34) (Zydus Cadila) 批准上市 Zydus cadila 骨质疏松症
Teriparatide acetate 醋酸特立帕肽 AK-159; MN-10-T; hPTH (1-34) acet. H2O 批准上市 USV, 益普生, 旭化成, 赛诺菲, Dong-A Pharmaceutical 低钙血症, 骨质疏松症 详情
Teriparatide 特立帕肽 hPTH-1-34; LY 333334; MN-10T 批准上市 礼来 FORTEO fda 骨质疏松症 LILLY 2002-11-26 骨质疏松症 详情
Teriparatide (Amega Biotech) 特立帕肽生物类似药(Amega Biotech) rhPTH (1-34) (Amega Biotech) 批准上市 Amega Biotech 骨质疏松症
Abaloparatide ITM-058; BIM-44058; BA-058; BA-058-SC; BA-058-TD,BA058,BIM44058,ITM058 批准上市 益普生, Radius Health TYMLOS fda 绝经后骨质疏松症 RADIUS HEALTH INC 2017-04-28 绝经后骨质疏松症 详情
Teriparatide biosimilar (Biosidus) 特立帕肽生物类似药(Biosidus) rhPTH (1-34) (Biosidus) 批准上市 Biosidus 骨质疏松症 详情
Teriparatide biosimilar (CinnaGen) 特立帕肽生物类似药(CinnaGen) rhPTH (1-34) (CinnaGen) 批准上市 CinnaGen 骨质疏松症
Parathyroid hormone (Shire) 甲状旁腺素(Shire) 423562; ALX-111; NPSP-795; NPSP-558; PTH (1-84); PTH 1-84; rhPTH (1-84); rhPTH-1-84; SB-423562; SHP-635; SHP-634 批准上市 Shire parathyroid hormone (rDNA) ema

Treatment of osteoporosis in postmenopausal women at high risk of fractures (see section 5.1).

A significant reduction in the incidence of vertebral, but not hip fractures has been demonstrated.

NPS Pharma Holdings Limited 2006-04-24 甲状旁腺机能减退, 骨质疏松症 详情

PTH1R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Ostabolin topical (Zelos) 临床二期 Zelos Therapeutics 银屑病
Parathyroid hormone 7-34 (IGI) PTH(7-34) 临床前 Teligent 脱发
AJT-240 AJT-240; SK-1403 临床三期 EA Pharma, JW pharmaceutical, 三和化学研究所, 天士力制药 甲状旁腺机能亢进 详情
ZYPH-0907 ZYPH-0907 临床一期 Zydus cadila 骨质疏松症
Parathyroid hormone (1-34) gel (TG Therapeutics) 临床一期 TG Therapeutics 银屑病
Teriparatide biosimilar (Stelis) SBL-001,SBL001,SBL 001 临床一期 Stelis Biopharma 骨质疏松症
Teriparatide liposomal cream (Manhattan Pharmaceuticals) 临床二期 波士顿大学, TG Therapeutics 银屑病
BIM-44002 BIM-44002 临床二期 益普生 高钙血症
Recombinant human parathyroid hormone (Green Cross) 临床二期 Green Cross 骨质疏松症
Teriparatide biosimilar (Shanghai CAS Shenglongda Biotech) 临床三期 上海中科生龙达生物 绝经后骨质疏松症
Recombinant parathyroid hormone (Beijing SL Pharmaceutical) 临床二期 北京双鹭药业 骨质疏松症
Teriparatide biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical) 临床一期 上海复旦张江生物医药 骨质疏松症
Ostabolin (Zelos) ZT-031 临床二期 Azelon Pharmaceuticals 髋部骨折, 绝经期症状, 绝经后骨质疏松症, 骨质疏松症
Teriparatide (Critical Pharmaceuticals) CP-046 临床一期 Critical Pharmaceuticals, 诺丁汉大学 骨质疏松症 详情
Recombinant parathyroid hormone (1-34) 临床三期 上海中科生龙达生物 绝经后骨质疏松症
Parathyroid hormone 1-84 (Kerun Biopharmaceutical) 临床二期 重庆科润生物医药, Heze Buchang Pharmaceutical 骨质疏松症 详情
PCO-371 PCO-371,PCO371 临床一期 中外制药 甲状旁腺机能减退 详情
Teriparatide biosimilar (Genemen Biotech) 临床阶段不明 苏州金盟生物技术有限公司 绝经后骨质疏松症, 男性骨质疏松症
KUR-115 KUR-115 临床一期 Kuros Biosciences, 百特 骨疾病
Recombinant human parathyroid hormone (Shenzhen Salubris Pharmaceuticals) G56-W1; rhPTH(1-34) 临床二期 信立泰 骨质疏松症 详情
Humanised anti-PTHrP antibody 临床二期 中外制药 高钙血症, 转移性癌症
KUR-111 KUR-111; I-0401 临床二期 Kuros Biosciences 骨折 详情
BMD-1221 BMD-1221 临床阶段不明 University of Arkansas System, BiologicsMD 骨折
Teriparatide biosimilar (Rhein Minapharm Biogenetics) 临床阶段不明 Rhein Minapharm Biogenetics 骨质疏松症
Teriparatide biosimilar (National Institute of Dental and Craniofacial Research) rhPTH (1-34) (National Institute of Dental and Craniofacial Research) 临床三期 National Institute of Dental and Craniofacial Research 原发性甲状腺功能减退症, 先天性胸腺发育不全 详情
Teriparatide transdermal (Corium International) 临床二期 Corium International 骨质疏松症 详情
Parathyroid hormone analog (oral,Unigene/GlaxoSmithKline) GSK-768974 临床二期 Unigene Laboratories 绝经后骨质疏松症
Recombinant human parathyroid hormone 1-34 (Shanghai United Cell Biotech) rhPTH (1-34) 临床三期 上海联合赛尔生物科技 骨质疏松症 详情
Teriparatide biosimilar (Dongguan Baolijian Bioengineer) 临床三期 东莞宝丽健生物工程 绝经后骨质疏松症
T3-sulfate (Bracco SpA) 临床二期 Bracco 甲状腺机能减退症
TransCon PTH ACP-014 临床二期 Ascendis Pharma 甲状旁腺机能减退
Teriparatide biosimilar (United Cell Biotechnology) 临床申请 上海联合赛尔生物科技 绝经后骨质疏松症, 男性骨质疏松症
Recombinant human parathyroid hormone (Beijing ShuangLu Pharmaceutical) 临床二期 北京双鹭药业 骨质疏松症
Hemoparatide hPTH-137 临床一期 Pharis Biotec 银屑病
Teriparatide transdermal (Zosano Pharma) B-104; B-106; TH-0229; ThPTH (1-34); ZP-PTH,B 104; B 106; TH 0229; ZP PTH,B104; B106; TH0229 临床二期 Zosano 绝经后骨质疏松症 详情
Teriparatide intranasal (Marina Biotech) 临床二期 Marina Biotech 骨质疏松症
KUR-112 (Kuros Biosciences) KUR-112; I-040302; TGplPTH1-34 临床一期 Kuros Biosciences 骨癌
Teriparatide transdermal (TransPharma) hPTH (1-34); ViaDerm-hPTH (1-34); ViaDor-hPTH (1-34) 临床二期 TransPharma Medical, 礼来 骨质疏松症
Teriparatide (Asubio Pharma) SUN-E3001; CHS-13340 临床二期 第一三共, 中外制药 绝经后骨质疏松症
Teriparatide (Azelon Pharmaceuticals) ZT-034 临床二期 Azelon Pharmaceuticals 绝经后骨质疏松症 详情
Recombinant Human Parathyroid Hormone (1-34), Shanghai Celgen Biopharmaceuticals 临床二期 Shanghai Celgen Bio 骨质疏松症
Recombinant parathyroid hormone 1-34 (Uni-Bio Science Group) rhPTH 1-34 (Uni-Bio Science Group);Uni-PH (1-34); Uni-rPH (1-34); Uni-PTH; UNI-PTH (1-34) BLA 申请 联康生物科技集团 绝经后骨质疏松症
Teriparatide oral (Bone Medical) BN-003,BN 003,BN003 临床二期 Botanix Pharmaceuticals 骨质疏松症
KUR-113 Fibrin-PTH; I-040202; KUR-113 临床二期 Kuros Biosciences 骨折 详情

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