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P-Selectin信息

英文名称:P-selectin
中文名称:P-选择素
靶点别称:PADGEM,GRMP,Selectin P (Granule Membrane Protein 140kD, Antigen CD62),Platelet Alpha-Granule Membrane Protein,Granulocyte Membrane Protein,CD62P Antigen,Antigen CD62,P-Selectin,GMP140,CD62P,CD62,PSEL,Platelet Activation Dependent Granule-External Membrane
上市药物数量:1
临床药物数量:3
最高研发阶段:批准上市

P-Selectin产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SEP-H52E4
Human
Human P-Selectin / CD62P Protein, His Tag
SEP-H5255
Human
Human P-Selectin / CD62P Protein, Fc Tag
 
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P-Selectin 分子别名

P-Selectin,CD62P,SELP,GMP-140

P-Selectin 分子背景

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

P-Selectin 参考文献

P-Selectin上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Crizanlizumab-tmca Sel-G1; SEG-101; Sel-G-1 批准上市 Selexys, 诺华制药 Adakveo EU 镰状细胞血症 Novartis Europharm Ltd 2019-11-15 阴茎异常勃起, 骨髓纤维化, 镰状细胞血症 详情

P-Selectin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Rivipansel Sodium GM-1070; GMI-1070; PF-6460031; PF-06460031-02; PF-06460031 (free base) 临床三期 Glycomimetics Pharmaceutical 肾脏疾病, 镰状细胞血症 详情
Inclacumab RG-1512; RO-4905417; LC-1004-002; DSM-ACC-2641; R-1512 临床二期 罗氏, Genmab 心肌梗塞, 外周血管疾病, 急性冠脉综合征, 血管移植物阻塞, 外周动脉疾病 详情
Dociparstat sodium ODSH; CX-01; PGX-100; PGX-ODSH-2013-AML-1 临床三期 Paringenix 新型冠状病毒肺炎, 胰腺癌, 急性髓细胞样白血病, 蛋白丢失性肠病, 慢性阻塞性肺疾病, 急性肺损伤 详情

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