搜索
 > 【P-Selectin】重组蛋白信息

P-Selectin信息

英文名称:P-selectin
中文名称:P-选择素
靶点别称:GMRP ,Leukocyte-endothelial cell adhesion molecule 3,CD_antigen=CD62P,GMP-140,SELP,LECAM3,Granule membrane protein 140,P-selectin,CD62 antigen-like family member P,PADGEM,Platelet activation dependent granule-external membrane protein,GRMP
上市药物数量:0
临床药物数量:8
最高研发阶段:BLA 申请

P-Selectin产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SEP-H52E4
Human
Human P-Selectin / CD62P Protein, His Tag
SEP-H5255
Human
Human P-Selectin / CD62P Protein, Fc Tag
 
评论(0)
 

P-Selectin 分子别名

P-Selectin,CD62P,SELP,GMP-140

P-Selectin 分子背景

P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM). SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets. In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies. In unactivated platelets SELP is stored in α-granules. The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan. Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.

P-Selectin 参考文献

P-Selectin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Bimosiamose TBC-1269 临床二期 Encysive, Revotar 斑块状银屑病, 特应性皮炎, 慢性阻塞性肺病, 哮喘 详情
Torapsel YSPSL 临床二期 辉瑞, Ys Therapeutics 再灌注损伤, 心肌梗塞, 移植后功能延迟恢复 详情
Inclacumab LC-1004-002; R-1512; RG-1512; DSM-ACC-2641; RO-4905417 临床二期 Genmab, 罗氏, Global Blood Therapeutics 急性冠脉综合征, 外周血管疾病, 心肌梗塞 详情
Crizanlizumab SEG-101; Sel-G1; Sel-G-1,SelG1 BLA 申请 Selexys, 诺华 镰刀状贫血症 详情
Dociparstat sodium CX-01; ODSH; PGX-100; PGX-ODSH-2013-AML-1 临床二期 ParinGenix, Cantex, Chimerix 骨髓增生异常综合征, 急性骨髓性白血病, 胰腺癌 详情
CY-1503 CY-1503 临床三期 Epimmune Inc., 大日本住友 再灌注损伤, 呼吸道疾病 详情
Rivipansel Sodium GM-1070; GMI-1070; PF-06460031-02; PF-06460031 (free base); PF-6460031 ,GMI1070,PF0646003102 临床三期 GlycoMimetics Pharmaceutical, 辉瑞 镰状细胞血管阻塞危象 详情
Monoclonal antibody EP-5C7  (PDL BioPharma) EP-5C7 临床一期 PDL BioPharma 中风, 自身免疫疾病, 银屑病, 休克, 哮喘

消息提示

请输入您的联系方式,再点击提交!

确定