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 > 【Osteoprotegerin】重组蛋白信息

Osteoprotegerin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
TNB-H5220
Human
Human Osteoprotegerin / TNFRSF11B Protein, His Tag
TNB-H5259
Human
Human TNFRSF11B /Osteoprotegerin Protein,C-Fc Tag,HEK293 expressed

Osteoprotegerin 分子别名

TNFRSF11B,OCIF,OPG,Osteoprotegerin

Osteoprotegerin 分子背景

Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Osteoprotegerin 参考文献

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