搜索
 > 【Osteoactivin】重组蛋白信息

Osteoactivin信息

英文名称:Transmembrane glycoprotein NMB
中文名称:跨膜糖蛋白NMB
靶点别称:Transmembrane Glycoprotein,HGFIN,Hematopoietic growth factor inducible neurokinin-1 type,GPNMB,Glycoprotein Nmb,Hematopoietic Growth Factor Inducible Neurokinin-1,Glycoprotein Nonmetastatic Melanoma Protein B,Transmembrane Glycoprotein HGFIN,Glycoprotein
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Osteoactivin产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GPB-H5229
Human
Human Osteoactivin / GPNMB Protein, His Tag
 
评论(0)
 

Osteoactivin 分子别名

GPNMB,HGFIN,NMB,Osteoactivin

Osteoactivin 分子背景

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin 参考文献

Osteoactivin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Glembatumumab vedotin CR-011; CDX-011; CR-011-ADC; CR011-vcMMAE 临床二期 Celldex 骨肉瘤, 乳腺癌, 鳞状细胞癌, 黑色素瘤 详情

消息提示

请输入您的联系方式,再点击提交!

确定