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MMP-9信息

英文名称:Matrix metalloproteinase 9
中文名称:基质金属蛋白酶-9
靶点别称:92 kDa gelatinase,Gelatinase B,GELB,82 kDa matrix metalloproteinase-9,Matrix metalloproteinase-9,92 kDa type IV collagenase,CLG4B,MMP9,67 kDa matrix metalloproteinase-9,MMP-9
上市药物数量:0
临床药物数量:15
最高研发阶段:临床三期

MMP-9产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MM9-H5221
Human
Recombinant Human MMP-9 / CLG4B Protein

MMP-9 分子别名

MMP9,CLG4B,GELB,MANDP2,Gelatinase B

MMP-9 分子背景

Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.

MMP-9 参考文献

MMP-9临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AQU-005 AQU-005; NMAQU-005; NM-AQU-005 临床一期 Aquilus Pharmaceuticals, NeuroMax 神经痛
RBx-10017609 临床二期 太阳制药, 葛兰素史克 慢性阻塞性肺病
ABT-518 ABT 518 临床一期 艾伯维 实体瘤
SD-7300 临床一期 辉瑞 实体瘤
PG-116800 PG-116800; PG-530742; PGE-7113313,PG116800; PG530742; PGE7113313,PG 116800; PG 530742; PGE 7113313 临床二期 宝洁 骨关节炎, 心力衰竭, 心肌梗塞 详情
Andecaliximab GS-5745,GS5745 临床三期 吉利德 胃癌, 溃疡性结肠炎, 实体瘤, 类风湿性关节炎, 克罗恩氏病, 慢性阻塞性肺病 详情
AZD-1236 AZD-1236 临床二期 阿斯利康 慢性阻塞性肺病 详情
Incyclinide CMT-3; COL-3; NSC-683551 临床二期 高德美 痤疮, 酒糟鼻 详情
S-3304 S-3304 临床二期 盐野义 实体瘤 详情
Tanomastat BAY-12-9566 临床三期 拜耳 小细胞肺癌, 非小细胞肺癌, 卵巢癌, 胰腺癌
AE-941 AE-941; NSC-706456 临床三期 AEterna Zentaris, 菲尔若, 辉瑞, 美国国立癌症研究所, 爱尔康 非小细胞肺癌, 肾癌 详情
RS-130830 RS-130830; CTS-1027; RO-1130830,RS130830,CTS1027,RO1130830 临床二期 罗氏, Conatus Pharmaceutical 关节炎, 丙肝 详情
CP-471358 CP-471358 临床一期 辉瑞 实体瘤
Abametapir Ha-44; BRN-0123183; HA-44; Ha44-Gel,Ha44,BRN0123183 临床三期 Hatchtech 头虱 详情
Rebimastat BMS-275291; D-2163 临床三期 Celltech, 百时美施贵宝 非小细胞肺癌 详情

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