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MMP-2信息

英文名称:Matrix metalloproteinase-2
中文名称:基质金属蛋白酶-2
靶点别称:PEX,TBE-1,MMP-2,Gelatinase A,CLG4A,MMP2,72 kDa type IV collagenase,72 kDa gelatinase,Matrix metalloproteinase-2
上市药物数量:0
临床药物数量:14
最高研发阶段:NDA 申请

MMP-2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
MM2-H5225
Human
Human MMP-2 Protein, His Tag
 
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MMP-2 分子别名

MMP2,CLG4,CLG4A,MMP-II,MONA,TBE-1

MMP-2 分子背景

Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 / CLG4A contains 3 fibronectin type-II domains and 4 hemopexin-like domains. MMP-2 is produced by normal skin fibroblasts. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. MMP2 involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin.

MMP-2 参考文献

MMP-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
131-I-Chlorotoxin TM-601-I-131; 131-I-TM-601 临床二期 TransMolecular, Morphotek 神经胶质瘤 详情
AQU-005 AQU-005; NMAQU-005; NM-AQU-005 临床一期 Aquilus Pharmaceuticals, NeuroMax 神经痛
ABT-518 ABT 518 临床一期 艾伯维 实体瘤
SD-7300 临床一期 辉瑞 实体瘤
PG-116800 PG-116800; PG-530742; PGE-7113313,PG116800; PG530742; PGE7113313,PG 116800; PG 530742; PGE 7113313 临床二期 宝洁 骨关节炎, 心力衰竭, 心肌梗塞 详情
Incyclinide CMT-3; COL-3; NSC-683551 临床二期 高德美 痤疮, 酒糟鼻 详情
XL-784 XL-784,XL784 临床二期 Exelixis, Symphony Evolution 糖尿病性肾病 详情
S-3304 S-3304 临床二期 盐野义 实体瘤 详情
Tanomastat BAY-12-9566 临床三期 拜耳 小细胞肺癌, 非小细胞肺癌, 卵巢癌, 胰腺癌
AE-941 AE-941; NSC-706456 临床三期 AEterna Zentaris, 菲尔若, 辉瑞, 美国国立癌症研究所, 爱尔康 非小细胞肺癌, 肾癌 详情
PNU-248686A PNU-248686A 临床一期 辉瑞 实体瘤
RS-130830 RS-130830; CTS-1027; RO-1130830,RS130830,CTS1027,RO1130830 临床二期 罗氏, Conatus Pharmaceutical 关节炎, 丙肝 详情
Abametapir BRN-0123183; DFD-11; HA-44; Ha44 Gel NDA 申请 Hatchtech 虱病 详情
Rebimastat BMS-275291; D-2163 临床三期 Celltech, 百时美施贵宝 非小细胞肺癌 详情

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