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MMP-1信息

英文名称:Matrix metalloproteinase-1
中文名称:基质金属蛋白酶-1
靶点别称:MMP-1,27 kDa interstitial collagenase,22 kDa interstitial collagenase,MMP1,Interstitial collagenase,Matrix metalloproteinase-1,Fibroblast collagenase,CLG
上市药物数量:0
临床药物数量:4
最高研发阶段:临床三期

MMP-1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
MM1-H5222
Human
Human MMP-1 Protein, His Tag
 
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MMP-1 分子别名

MMP1,CLG,CLGN

MMP-1 分子背景

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) is also known as interstitial collagenase and fibroblast collagenase. MMP­1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 breaks down the interstitial collagens, types I, II, and III. MMP­1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, myelin basic protein, L­Selectin, pro­TNF, IL­1β, IGF­BP3, IGF­BP5, pro MMP­2 and pro MMP­9.

MMP-1 参考文献

MMP-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
FCX-013 FCX-013,FCX013; FCX 013 临床申请 Fibrocell Science 系统性硬化症 详情
CP-471358 CP-471358 临床一期 辉瑞 实体瘤
Rebimastat BMS-275291; D-2163 临床三期 Celltech, 百时美施贵宝 非小细胞肺癌 详情
BT-1718 BDC-17; BT-1718 临床二期 Bicycle Therapeutics 实体瘤 详情

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