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MCAM信息

英文名称:Melanoma cell adhesion molecule
中文名称:黑色素瘤细胞粘附分子
靶点别称:Melanoma cell adhesion molecule,MUC18,CD146,Cell surface glycoprotein P1H12,Melanoma-associated antigen A32,S-endo 1 endothelial-associated antigen,MCAM,Melanoma-associated antigen MUC18
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

MCAM产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CD6-H5229
Human
Human MCAM / CD146 Protein, His Tag
CD6-H5253
Human
Human CD146 MCAM Protein,With C-Fc Tag

MCAM 分子别名

MCAM,CD146,MUC18

MCAM 分子背景

CD146 is also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.

MCAM 参考文献

MCAM临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Imaprelimab PRX-003 临床一期 Neotope Biosciences, Onclave Therapeutics, Prothena 银屑病 详情
MG1MA3 MG1-MAGEA3; MG1-MA3; Ad-MG1 临床二期 University of Ottawa Heart Institute, McMaster University, Children's Hospital of Eastern Ontario, Turnstone Biologics 实体瘤 详情
Anti-MUC18 monoclonal antibody 临床一期 Abgenix 黑色素瘤

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