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IL-33信息

英文名称:Interleukin-33
中文名称:白细胞介素-33
靶点别称:IL1F11,IL33,IL-33,NF-HEV,NFHEV,Interleukin-1 family member 11,IL-1F11,Nuclear factor from high endothelial venules,C9orf26
上市药物数量:0
临床药物数量:3
最高研发阶段:临床二期

IL-33产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
IL3-H52H7
Human
Human IL-33 Protein, His Tag

IL-33 分子别名

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

IL-33 分子背景

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 参考文献

IL-33临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
LY-3375880 LY-3375880,LY3375880,LY 3375880 临床二期 礼来 特应性皮炎 详情
Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi) REGN-3500; SAR-440340 临床二期 再生元制药, 赛诺菲 过敏性哮喘, 慢性阻塞性肺病 详情
Etokimab ANB-020 临床二期 AnaptysBio 特应性皮炎, 过敏症, 鼻窦炎, 哮喘 详情

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