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IL-12B信息

英文名称:Interleukin-12 subunit beta
中文名称:白细胞介素-12β亚基
靶点别称:NKSF2,IL-12B,Interleukin-12 subunit beta,CLMF p40,IL-12 subunit p40,IL12B,NK cell stimulatory factor chain 2,Cytotoxic lymphocyte maturation factor 40 kDa subunit
上市药物数量:0
临床药物数量:3
最高研发阶段:临床三期

IL-12B产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
NK2-H52H7
Human
Human IL-12B / NKSF2 / p40 Protein, His Tag
NK2-H5258
Human
Human IL12B /P40 Protein,C-Fc Tag,HEK293 expressed
 
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IL-12B 分子别名

IL12B,CLMF,CLMF2,NKSF,NKSF2,p40

IL-12B 分子背景

Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.

IL-12B 参考文献

IL-12B临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Esonarimod KE-298 临床三期 大正 类风湿性关节炎
HP-228 HP-228; ILP-228 临床二期 Sygnis 肥胖症, 2型糖尿病, 术后疼痛, 炎症
Y-25510 Y-25510 临床一期 田边三菱制药 白细胞减少症, 血小板减少症

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