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IL-10信息

英文名称:Interleukin-10
中文名称:白细胞介素-10
靶点别称:CSIF,IL10,IL-10,Cytokine synthesis inhibitory factor,Interleukin-10
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

IL-10产品列表

产品库
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IL0-H4248
Human
Human IL-10 Protein, His Tag
IL0-M4248
Mouse
Mouse IL-10 Protein, His Tag
 
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IL-10 分子别名

CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10

IL-10 分子背景

Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production. Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract. Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.

IL-10 参考文献

IL-10临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
HMPL-011 HMPL-011 临床一期 和记黄埔医药 自身免疫疾病 详情
PUR-0110 PUR-0110; PCT-233 临床二期 PurGenesis Technologies 溃疡性结肠炎 详情
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 临床二期 利奥制药 银屑病, 特应性皮炎 详情
CC-11006 CC-11006 临床一期 新基 骨髓增生异常综合征, 炎症 详情
Recombinant interleukin-10 (psoriasis), National Cancer Institute rhIL-10 临床二期 美国国立癌症研究所 银屑病
Anti-Human IL10 Therapeutic Antibody SCH-708980,SCH 708980,SCH708980 临床二期 国家过敏和传染病研究所 内脏利什曼病 详情
MK-1966 MK-1966,MK 1966,MK1966 临床一期 默沙东, Dynavax 血液系统恶性肿瘤 详情
BT-063 BT-063 临床二期 Biotest 系统性红斑狼疮 详情

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