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GITR信息

英文名称:Glucocorticoid-induced tumor necrosis factor receptor-related protein
中文名称:糖皮质激素诱导的肿瘤坏死因子受体相关蛋白
靶点别称:Glucocorticoid-induced tumor necrosis factor receptor-related protein,CD357,AITR,GITR,Activation-inducible TNFR family receptor,TNFRSF18,UNQ319/PRO364,Glucocorticoid-induced TNFR-related protein
上市药物数量:0
临床药物数量:12
最高研发阶段:临床二期

GITR产品列表

 
评论(1)
GIR-H5228|Human GITR / TNFRSF18 Protein, His Tag
  1. 151XXXXXXX3
  2. 0人赞
  3. 使用Acro的产品很久了,不管是产品还是技术,每次都是有问题及时解决。用过的GITR蛋白,做过SPR实验,6个浓度梯度做,拟合曲线也很不错,数据也是达到我的预期,希望以后还是合作愉快。
  4. 2019-09-27
 

GITR 分子别名

AITR,GITR,TNFRSF18,CD357

GITR 分子背景

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR 参考文献

GITR临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ASP-1951 ASP-1951; PTZ-522 临床一期 Potenza Therapeutics, 安斯泰来 实体瘤 详情
Anti-GITR antibody (BMS) 临床一期 百时美施贵宝 实体瘤
MK-1248 MK-1248 临床一期 默沙东 实体瘤 详情
Efgivanermin alfa MEDI-1873 临床一期 MedImmune 实体瘤 详情
AMG-228 AMG-228 临床一期 安进 实体瘤 详情
OMP-336B11 OMP-336B11 临床一期 OncoMed Pharmaceuticals 实体瘤 详情
TRX-518 TRX-518 临床二期 Tolerx, Leap Therapeutics 前列腺癌, 实体瘤, 卵巢癌, 黑色素瘤 详情
ATOR-1144 ATOR-1144 临床前 Alligator Bioscience 血液系统恶性肿瘤, 实体瘤
INCAGN-1876 INCAGN-1876 临床二期 Agenus, 路德维格癌症研究所, Incyte 实体瘤 详情
GWN-323 GWN-323 临床一期 诺华 实体瘤, 淋巴瘤 详情
BMS-986156 BMS-986156,BMS 986156 临床二期 百时美施贵宝 实体瘤 详情
MK-4166 MK-4166 临床一期 默沙东 实体瘤, 成胶质细胞瘤 详情

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