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 > 【GFR alpha-2】重组蛋白信息

GFR alpha-2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
GF2-H5225
Human
Human GFR alpha-2 Protein, His Tag

GFR alpha-2 分子别名

GFRA2,GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2

GFR alpha-2 分子背景

GDNF family receptor alpha-2 (GFRA2) is also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.

GFR alpha-2 参考文献

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