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 > 【GFR alpha-1】重组蛋白信息

GFR alpha-1产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
GF1-H5224
Human
Human GFR alpha-1 Protein, His Tag
GF1-H5252
Human
Recombinant Human GFR alpha-1 / GFRA1 Protein
 
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GFR alpha-1 分子别名

GFRA1,GDNFRA,RETL1,TRNR1,GDNFR,GFR-ALPHA-1,RET1L

GFR alpha-1 分子背景

GDNF family receptor alpha-1 (GFRA1) is also known as RET ligand 1 (RETL1), TGF-beta-related neurotrophic factor receptor 1 (TRNR1), is a novel glycosylphosphatidylinositol (GPI)-linked cell surface receptor, and belongs to the glial cell line-derived neurotrophic factor (GDNF) receptor subfamily. The GDNF family ligands comprises GDNF, Neurturin (NTN), Artemin, and Persephin. GDNF and NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA1 mediates the association with and activation of the RET tyrosine kinase receptor (RTK), and subsequently initiates the RET signaling pathway. GFR alpha-mediated signaling plays an important role in the survival, differentiation, and migration of central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system, as well as the inflammatory response in some carciniomas.

GFR alpha-1 参考文献

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