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FOLR2信息

英文名称:Folate receptor beta
中文名称:叶酸受体β
靶点别称:Placental folate-binding protein,Folate receptor 2,FOLR2,Folate receptor beta,FR-beta,FBP,Folate receptor, fetal/placental
上市药物数量:0
临床药物数量:6
最高研发阶段:临床三期

FOLR2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
FO2-H5223
Human
Human FOLR2 Protein, His Tag

FOLR2 分子别名

FOLR2,BETA-HFR,FBP/PL-1,FR-BETA,FR-P3,FBP

FOLR2 分子背景

Folate receptor beta is also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family. and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

FOLR2 参考文献

FOLR2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Vintafolide MK-8109; EC-145,MK8109,MK 8109 临床二期 Endocyte, 默沙东 非小细胞肺癌 详情
EC-1456 EC-1456; EC-0531,EC1456,EC0531 临床一期 Endocyte 非小细胞肺癌, 实体瘤 详情
EC-0905 EC-0905 临床前 Endocyte 癌症
OTL-38 OTL-38; OTL-0038; Pteroyl-L-Tyr-S0456; EC-17 临床三期 On Target 卵巢癌 详情
Epofolate BMS-753493 临床二期 百时美施贵宝, Endocyte 实体瘤 详情
EC-0305 EC-0305; F-0305 临床一期 Endocyte 实体瘤

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