搜索
 > 【FOLR1】重组蛋白信息

FOLR1信息

英文名称:Folate receptor alpha
中文名称:叶酸受体α
靶点别称:FOLR1,Folate receptor 1,FR-alpha,FOLR,Adult folate-binding protein,Folate receptor, adult,Folate receptor alpha,KB cells FBP,Ovarian tumor-associated antigen MOv18,FBP
上市药物数量:0
临床药物数量:15
最高研发阶段:临床三期

FOLR1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
FO1-H5229
Human
Recombinant Human FOLR1 Protein
FO1-H528b
Human
Recombinant Human FOLR1 Protein
FO1-M5225
Mouse
Mouse FOLR1 Protein, His Tag
FO1-M82E9
Mouse
Biotinylated Mouse FOLR1 Protein, His Tag, Avi Tag
FO1-C52H8
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque FOLR1 Protein, His tag
FO1-H82E2
Human
Biotinylated Human FOLR1 Protein, His,Avitag
FO1-H5253
Human
Human FOLR1 Protein, Fc Tag
FO1-H82F9
Human
Biotinylated Human FOLR1 Protein, Fc Tag, Avi Tag

FOLR1 分子别名

FOLR-1,FBP,FOLR

FOLR1 分子背景

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

FOLR1 参考文献

FOLR1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GALE-302 GALE-302; E-39; J-65 临床二期 Galena Biopharma 乳腺癌, 卵巢癌
OCTR lymphocytes (Centocor) 临床二期 强生 卵巢癌
MOv18 IgE (King's College London) 临床一期 伦敦国王学院, Cancer Research UK 癌症 详情
Vintafolide MK-8109; EC-145,MK8109,MK 8109 临床二期 诺华, 默沙东 非小细胞肺癌 详情
EC-1456 EC-1456; EC-0531,EC1456,EC0531 临床一期 诺华 非小细胞肺癌, 实体瘤 详情
Mirvetuximab soravtansine IMGN-853; M9346-Asulfo-SPDB-DM4,IMGN853; M-9346-Asulfo-SPDB-DM4 临床三期 ImmunoGen 输卵管癌, 子宫内膜癌症, 乳腺癌, 实体瘤, 腹膜癌, 卵巢癌 详情
EC-0905 EC-0905 临床前 诺华 癌症
MORAb-202 MORAb-202,MORAb202; MORAb 202 临床一期 Morphotek 实体瘤 详情
OTL-38 OTL-38; OTL-0038; Pteroyl-L-Tyr-S0456; EC-17 临床三期 On Target 卵巢癌 详情
Epofolate BMS-753493 临床二期 百时美施贵宝, 诺华 实体瘤 详情
Anti-CD3-anti-MOv18 monoclonal antibody 临床二期 Centocor 卵巢癌
NMI-500 临床一期 Nemucore Medical Innovations 乳腺癌, 卵巢癌
EC-0305 EC-0305; F-0305 临床一期 诺华 实体瘤
Noscapine-folate conjugate 临床一期 埃默里大学 免疫炎症, 实体瘤, 血液癌症
Farletuzumab MORAb-003,MORAb003 临床三期 Morphotek 卵巢癌 详情

消息提示

请输入您的联系方式,再点击提交!

确定