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E-Selectin信息

英文名称:Selectin E
中文名称:选择素-E
靶点别称:Leukocyte-endothelial cell adhesion molecule 2,SELE,E-selectin,LECAM2,ELAM1,CD_antigen=CD62E,ELAM-1,Endothelial leukocyte adhesion molecule 1,CD62 antigen-like family member E
上市药物数量:0
临床药物数量:11
最高研发阶段:临床三期

E-Selectin产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CDE-H5222
Human
Human E-Selectin / CD62E Protein, His Tag
CDE-H5250
Human
Recombinant Human E-Selectin / CD62E Protein
 
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E-Selectin 分子别名

SELE,RP1-117P20.2,CD62E,ELAM1,ESEL,LECAM2,E-Selectin

E-Selectin 分子背景

E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.

E-Selectin 参考文献

E-Selectin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GI-270384X GI-270384X; GI-270384 临床二期 葛兰素史克 炎症性肠病 详情
Bimosiamose TBC-1269 临床二期 Encysive, Revotar 斑块状银屑病, 特应性皮炎, 慢性阻塞性肺病, 哮喘 详情
Uproleselan GMI-1271 临床三期 GlycoMimetics Pharmaceutical 深静脉血栓, 干细胞移植, 多发性骨髓瘤, 急性骨髓性白血病 详情
E-selectin targeting humanized antibody (LifeArc) 临床一期 LifeArc 脓毒症, 成人呼吸窘迫综合征
CY-1787 临床一期 Epimmune Inc., 大日本住友 全身炎症反应综合征, 感染性休克, 过敏性鼻炎
CY-1503 CY-1503 临床三期 Epimmune Inc., 大日本住友 再灌注损伤, 呼吸道疾病 详情
Rivipansel Sodium GM-1070; GMI-1070; PF-06460031-02; PF-06460031 (free base); PF-6460031 ,GMI1070,PF0646003102 临床三期 GlycoMimetics Pharmaceutical, 辉瑞 镰状细胞血管阻塞危象 详情
Recombinant E-selectin (Novavax/NINDS) 临床二期 National Institute of Neurological Disorders and Stroke, Novavax 中风, 心肌梗塞 详情
CDP-850 CDP-850 临床二期 Celltech 银屑病
GMI-1359 GMI-1359 临床一期 GlycoMimetics Pharmaceutical 实体瘤 详情
Monoclonal antibody EP-5C7  (PDL BioPharma) EP-5C7 临床一期 PDL BioPharma 中风, 自身免疫疾病, 银屑病, 休克, 哮喘

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