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Erythropoietin R信息

英文名称:Erythropoietin receptor
中文名称:促红细胞生成素受体
靶点别称:EPOR,Erythropoietin receptor,EPO-R
上市药物数量:66
临床药物数量:55
最高研发阶段:批准上市

Erythropoietin R产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
EPR-H5253
Human
Human EPOR Erythropoietin Receptor With C-Fc Tag

Erythropoietin R 分子别名

EPOR

Erythropoietin R 分子背景

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis , and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR is a type 1 single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR pre-exists as dimers which upon binding of a 34 kDa ligand erythropoietin (Epo), changes its homodimerized state. These conformational changes result in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor. Erythropoietin is necessary to maintain endothelial cells and to promote tumor angiogenesis, hence the dysregulation of EpoR may affect the growth of certain tumors. EpoR signaling prevents neuronal death and ischemic injury.

Erythropoietin R 参考文献

Erythropoietin R上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Erythropoietin biosimilar (Fresenius Kabi Oncology) 批准上市 Fresenius Kabi 贫血
Recombinant human erythropoietin (Daying Pharma) 重组人红细胞生成素(大鹰药业) 批准上市 大鹰药业 贫血
Epoetin alfa biosimilar (Wockhardt) 批准上市 Wockhardt 贫血
Epoetin alfa biosimilar (Sedico) 批准上市 Sedico 贫血
Methoxy polyethylene glycol-epoetin beta RO-0503821 ; Ro-50-3821; CERA; R-1744; R-744; RG-744,Ro503821 批准上市 罗氏, 中外制药, Galenica Methoxy polyethylene glycol-epoetin beta ema

Treatment of symptomatic anaemia associated with chronic kidney disease (CKD).

The safety and efficacy of Mircera therapy in other indications has not been established.

Roche Registration GmbH 2007-07-20 贫血 详情
Erythropoietin biosimilar (Unilab/Biomedis) 批准上市 Unilab, Biomedis 贫血 详情
Epoetin alfa KRN-5702,KRN5702 批准上市 安进, 杨森, 协和发酵麒麟 Epoetin alfa 日本 贫血 协和发酵麒麟 1990-01-23 00:00:00.0 同种异体红细胞输血, 贫血 详情
Epoetin beta BM-06.019; BM-06019; RO-205-3859 批准上市 罗氏, 中外制药, 亿腾医药 Recormon hma 贫血 Boehringer Mannheim GmbH
Sandhofer Str. 116
D-68305 Mannheim
1996-03-05 贫血 详情
Erythropoietin biosimilar (RPG Life Sciences) 批准上市 RPG Life Sciences 贫血
Recombinant erythropoietin biosimilar (Lupin) 重组人促红素生物类似药(Lupin) 批准上市 Lupin 贫血
Recombinant erythropoietin (Cadila Pharmaceuticals) 重组人促红素(Cadila Pharmaceuticals) 批准上市 Cadila Pharmaceuticals 贫血 详情
Recombinant human erythropoietin biosimilar (North China Pharmaceutical Corporation) 重组人促红素(华北制药金坦生物技术) 批准上市 华北制药 Recombinant Human Erythropoietin Injection(CHO Cell) cfda 贫血 2015-09-01 贫血
Recombinant erythropoietin biosimilar (Elea) 批准上市 Elea 贫血
Epoetin alfa biosimilar (Claris Lifesciences) 批准上市 Claris Lifesciences 贫血 详情
Erythropoietin (Dong-A ST) DA-3285 批准上市 Dong-A Pharmaceutical, Dem Ilac 贫血 详情
Erythropoietin biosimilar (Shantha Biotechnics) 批准上市 Shantha Biotechnics 贫血
Epoetin alfa biosimilar (Sun Pharmaceutical Industires) 批准上市 Ranbaxy Laboratories, 太阳制药 贫血
Erythropoietin biosimilar (Neiss Labs) 批准上市 Neiss Labs 贫血
Erythropoietin biosimilar (Incepta Pharmaceuticals) 批准上市 Incepta Pharmaceuticals 贫血
Epoetin alfa biosimilar(PT Kalbe) 批准上市 Kalbe Farma 慢性肾脏病贫血, 化疗引起的贫血
Erythropoietin biosimilar (Klarvoyant Biogenics) 批准上市 Klarvoyant 贫血
Epoetin alfa biosimilar (CJ Corp) 批准上市 CJ, RG Pharmaceutica, Macropharma 贫血 详情
Recombinant human erythropoietin alfa (Daewoong Pharmaceutical) DWP-413,DWP 413,DWP413 批准上市 大熊制药 贫血
Recombinant erythropoietin long-acting (Shandong Kexing Bioproducts) 长效重组促红细胞生成素 批准上市 山东科兴生物制品有限公司 贫血
Epoetin omega HP-EPO-CRF 批准上市 Elanex Pharma Group 贫血 详情
Erythropoietin biosimilar (Micro Labs) 批准上市 Micro Labs 贫血
Darbepoetin alfa biosimilar (Dr Reddy's) 批准上市 Dr Reddys Laboratories 贫血
Recombinant human erythropoietin (Center of Molecular Immunology) 批准上市 Center of molecular immunology 再生障碍性贫血
Epoetin alfa biosimilar (Biosidus) 批准上市 Biosidus 贫血 详情
Erythropoietin biosimilar (VHB Life Sciences) 批准上市 VHB Life Sciences 贫血
Erythropoietin biosimilar (Center for Genetic Engineering and Biotechnology) 批准上市 Center for Genetic Engineering and Biotechnology 贫血
Darbepoetin alfa biosimilar (Torrent) 批准上市 Torrent Pharmaceuticals 贫血
Recombinant human erythropoietin (Shenzhen Xinpeng Bio-tech) 重组人促红素注射液(未名新鹏) 批准上市 深圳新鹏生物工程有限公司 Recombinant Human Erythropoietin Injection(CHO Cell) cfda 贫血 2015-09-08 贫血
Epoetin alfa biosimilar (Dragon Pharmaceutical) BR-05001 批准上市 Dragon 贫血
Epoetin alfa biosimilar (Emcure) 批准上市 Emcure 贫血
Epoetin zeta SB-309, EPO-zeta, Epoetin Hospira 批准上市 BIOCEUTICALS Arzneimittel, Hospira, STADA Arzneimittel epoetin zeta ema
  • Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients

    • Treatment of anaemia associated with chronic renal failure in adult and paedi

Stada Arzneimittel AG 2007-12-18 贫血 详情
Recombinant human erythropoietin (CHO Cell), Harbin Pharmaceutical Group Bioengineering 重组人促红素(CHO细胞) (哈药集团生物工程有限公司) 批准上市 哈药集团 贫血
Recombinant human erythropoietin (3SBio/Biolotus) 重组人促红素(3SBio/Biolotus) EPIAO; rhEPO 批准上市 沈阳三生制药, Biolotus 贫血 详情
Recombinant human erythropoietin (Beijing Four Rings Bio-Pharmaceutical) 批准上市 北京四环生物制药有限公司 贫血
Darbepoetin alfa biosimilar (Hetero Drugs) 批准上市 Hetero Drugs 贫血
Epoetin beta biosimilar (CinnaGen) 批准上市 CinnaGen 贫血 详情
Epoetin theta 批准上市 梯瓦 epoetin theta ema

Treatment of symptomatic anaemia associated with chronic renal failure in adult patients.

Treatment of symptomatic anaemia in adult cancer patients with non-myeloid malignancies receiving chemotherapy.

Teva GmbH 2009-10-23 贫血
Epoetin alfa biosimilar (Biocon) 批准上市 Biocon BioPharmaceuticals 贫血
Epoetin alfa biosimilar (LG Life Sciences) EPO 批准上市 LG Life Sciences 贫血 详情
Epoetin alfa biosimilar (Siam Bioscience) 批准上市 Siam Bioscience 贫血
Recombinant erythropoietin biosimilar (Recpharma) 重组人促红素生物类似药(Recpharma) 批准上市 ReceptoPharm 贫血 详情
Epoetin alfa biosimilar (Laboratorios Bioprofarma) 批准上市 Laboratorios Bioprofarma 贫血
Epoetin alfa biosimilar (Sandoz) HX-575; HX 575; HX575 批准上市 山德士, Medice Arzneimittel, Hexal epoetin alfa ema

Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients:

  • treatment of anaemia associated with chronic renal failure in paediatric and adult patients o
Hexal AG 2007-08-27 贫血 详情
Epoetin alfa biosimilar (Laboratorio Varifarma) 批准上市 Laboratorio Varifarma 贫血
Recombinant human erythropoietin (Chengdu Diao Group) 批准上市 成都地奥集团 贫血
Darbepoetin alfa Epo-N47; KRN-321; N-47 批准上市 安进, 协和发酵麒麟, Dompe Farmaceutici darbepoetin alfa ema

Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adults and paediatric patients.

Treatment of symptomatic anaemia in adult cancer patients with non-myeloid malignancies receiving c

Amgen Europe B.V. 2001-06-08 贫血 详情
Epoetin beta biosimilar (Pharmapark) 批准上市 Pharmapark 贫血
Erythropoietin biosimilar (Zuventus Healthcare) 批准上市 Zuventus Healthcare 贫血
Epoetin alfa biosimilar (Intas BioPharmaceuticals) 批准上市 Intas Biopharmaceuticals 贫血
Epoetin biosimilar (Zydus Cadila) 批准上市 Zydus cadila 贫血
Epoetin alfa biosimilar (Amega Bitoech) 批准上市 Amega Biotech 贫血
Epoetin alfa biosimilar (Nanogen) 批准上市 Nanogen Biopharmaceutical Co 贫血
Human erythropoietin biosimilar (Celon Laboratories) 批准上市 Celon Laboratories 贫血
Epoetin alfa biosimilar (Reliance Life Sciences) 批准上市 GeneMedix Plc, Reliance Life Sciences, Stragen Pharma 贫血
Recombinant erythropoietin (Shanghai Chemo Wanbang Biopharma) 批准上市 上海凯茂生物医药 贫血
Epoetin kappa (JCR Pharmaceuticals) JR-013,JR013 批准上市 JCR Pharmaceuticals, Kissei Epoetin kappa (JCR Pharmaceuticals) 日本 贫血 JCR Pharmaceuticals 2010-01-20 00:00:00.0 贫血
Erythropoietin biosimilar (Genius Biotherapeutics) 批准上市 Genius Biotherapeutics 贫血
Recombinant human erythropoietin (Shandong Ahua Biochemical) 批准上市 山东阿华生物药业 贫血
Epoetin alfa biosimilar (Blau Farmaceutica) 批准上市 Blau Farmaceutica 贫血 详情
Epoetin alfa (Pooyesh Darou Pharmaceuticals) 阿法依伯汀 批准上市 Pooyesh Darou 贫血
Epoetin alfa biosimilar (Fiocruz/Bio-Manguinhos) 批准上市 Fundacao Oswaldo Cruz (FIOCRUZ) 贫血 详情

Erythropoietin R临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Epoetin alfa biosimilar (Apotex) APO-EPO 临床三期 Apotex 贫血
CKD-11101 CKD-11101 临床三期 Chong Kun Dang 贫血
Recombinant human erythropoietin (Max Planck Institute) 临床二期 Max Planck Institute of Experimental Medicine 精神分裂症, 多发性硬化症
Erythropoietin (Epoplus) 临床一期 Cytonet 外伤, 肾衰竭
Recombinant human erythropoietin-Fc fusion protein (Dongguan baolijian Biotech) 临床一期 东莞宝丽健生物工程 贫血
Recombinant erythropoietin (Prolong Pharmaceuticals/Zydus Cadila) PEG-EPO; ZY-7318 临床一期 Prolong Pharmaceuticals, Zydus cadila 贫血 详情
Recombinant human erythropoietin (Hanyang University Seoul Hospital) 临床二期 汉阳大学 肌萎缩性脊髓侧索硬化症 详情
Erythropoietin (Y-shaped pegylation, Xiamen Amoytop Biotech) 临床一期 厦门特宝生物工程股份有限公司, BioGeneric 贫血
Long-acting erythropoietin (Teva) 临床前 CSL Behring, 梯瓦 贫血
R-1516 R-1516 临床一期 Gryphon Therapeutics, 罗氏 贫血
Peginesatide acetate AF-37702; Peptidic ERA 撤市 Affymax, 武田 贫血 详情
LU AA 24493 Lu-AA24493 临床二期 Warren Pharmaceuticals, 灵北制药 弗里德希氏共济失调, 中风 详情
CNTO528 CNTO-528; CNTO 528; CNTO528 临床一期 Centocor, 杨森, 强生 贫血
rhEPO-Fc (Shanghai Meiye Biotechnology) 临床一期 上海美烨生物 贫血
Pegylated recombinant human erythropoietin (Shenzen Saibaoer Biotech) 临床一期 深圳赛保尔生物药业 慢性肾脏病贫血
Erythropoietin (Neose) NE-180 临床二期 Neose Technologies 贫血
Darbepoetin alfa biosimilar (Biocad) BCD-066 临床三期 Biocad 贫血 详情
Erythropoietin biosimilar (AXXO) 临床阶段不明 AXXO 化疗引起的贫血
Darbepoetin alfa biosimilar (AvesthaGen) 临床三期 Avesthagen, 昆泰 贫血
Recombinant human erythropoietin-Fc fusion protein (Shanhai meiye Biotech) rhEPO-Fc 临床二期 上海美烨生物 贫血
Recombinant human erythropoietin (Uni-Bio Science Group) rhEPO-Fc 临床一期 联康生物科技集团 贫血 详情
Albumin-erythropoietin fusion protein (Tianjin SinoBiotech) 临床一期 天津溥瀛生物技术有限公司 贫血
GX-E2 EPO-hFC; EPO-hybrid-Fc; EPO-hyFc; GC-1113; GX-E2 临床二期 Genexine, Green Cross, 上海凯茂生物医药 贫血 详情
PEGylated erythropoietin (Intas Biopharmaceuticals) 临床三期 Intas Biopharmaceuticals 贫血
NTx-488 NTx-488 临床前 Trillium Therapeutics Inc 多发性硬化症
Recombinant human erythropoietin-CTP fusion protein (Harbin Pharmaceutical) 临床一期 哈药集团 贫血
Recombinant human erythropoietin-Fc fusion protein (Dongguan Baolijian Bioengineer) 临床一期 东莞宝丽健生物工程 贫血
Pegylated darbepoetin beta BCD-131 临床二期 Biocad 贫血 详情
Darbepoetin alfa biosimilar (Kyowa Hakko Kirin) BLA 申请 协和发酵麒麟 贫血
Recombinant human erythropoietin (Snow Brand Milk Products) 临床三期 雪印乳业 血液病
Epoetin delta (Shire) GA-EPO,MDL-104396,HMR-4396 撤市 Shire, 赛诺菲 肾衰竭, 贫血
Recombinant erythropoietin (Syntonix) 临床一期 百健艾迪 贫血
Epoetin alfa biosimilar (PanGen Biotech) PDA-10 临床三期 PanGen Biotech 贫血
Darbepoetin alfa biosimilar (CJ Healthcare) CJ-40001,YLB217 临床二期 CJ CheilJedang, 华北制药 贫血
Recombinant human erythropoietin (Shanghai Huaxin) 临床申请 上海华新生物高技术有限公司 贫血
Pegylated darbepoetin alfa biosimilar (Merck & Co.) MK-2578 临床二期 默沙东 贫血 详情
MDGN-201 MDGN-201 临床二期 Aevi Genomic Medicine 贫血 详情
Darbepoetin alfa biosimilar (Nichi-Iko Pharmaceutical/Aprogen) AP-032 临床前 Aprogen, Nichi-Iko Pharmaceutical 贫血
Darbepoetin alfa biosimilar (PanPharmaceuticals) 临床阶段不明 PanPharmaceuticals 贫血
Pegol-Sihematide EPO-018B 临床二期 江苏豪森医药 骨髓增生异常综合征, 贫血 详情
Recombinant erythropoietin (Bio-Ker) 临床阶段不明 Bio-Ker 不明
Darbepoetin alfa biosimilar (JCR Pharmaceuticals/Kissei Pharmaceutical) JR-131 BLA 申请 Kissei, JCR Pharmaceuticals 贫血 详情
Erythropoietin long-acting (Hanmi) HM-10760A; LAPS-EPO,HM 10760A; LAPS EPO,HM10760A 临床一期 韩美 贫血
Recombinant erythropoietin (XTL) EPO-XTL; rHuEPO-XTL 临床一期 Bio-GAL, XTL Biopharmaceuticals 多发性骨髓瘤
Erythropoietin polysialic (Xenetic Biosciences) PSA-EPO; SYN-20070131RU 临床三期 Lipoxen Technologies, Serum Institute of India, Xenetic Biosciences, SynBio 贫血
Novel erythropoiesis stimulant (Centergene) 临床一期 苏州晟济药业有限公司, 苏州康聚生物技术有限公司, 上海强邦生物科技有限公司 贫血
Erythropoietin biosimilar (Pooyesh Darou) 临床二期 Pooyesh Darou 贫血
Erythropoietin receptor agonist (Biocad) 临床一期 Biocad, Ligand 血液病
Recombinant erythropoietin fusion protein (Merck Serono) 临床一期 默克雪兰诺 贫血
Erythropoietin biobetter (Nautilus/HanAll) HL-033 临床一期 Nautilus Biotech, HanAll 贫血
Epoetin alfa biosimilar (Biocad) 临床一期 Biocad 贫血
Darbepoetin alfa biosimilar (Reliance Life Sciences) RTPR-026; R-TPR-026 临床三期 Reliance Life Sciences 贫血
Darbepoetin alfa biosimilar (Dong-A ST) DA-3880; GBS-011 BLA 申请 Dong-A Pharmaceutical, 三和化学研究所 贫血 详情
Darbepoetin alfa biosimilar (3SBio) NuPIAO,SSS-06,SSS 06 临床二期 沈阳三生制药 贫血
Epoetin beta biosimilar (Biocad) 临床一期 Biocad 贫血

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