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Ephrin-A4信息

英文名称:Ephrin-A4
中文名称:肝配蛋白A4
靶点别称:LERK-4,EPH-related receptor tyrosine kinase ligand 4,EPLG4,LERK4,EFNA4
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

Ephrin-A4产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
EA4-H5229
Human
Recombinant Human Ephrin-A4 / EFNA4 / EPLG4 Protein
EA4-H5250
Human
Human Ephrin A4 /EFNA4 Protein,C-Fc Tag

Ephrin-A4 分子别名

EFNA4,EPLG4,LERK4,Ephrin-A4

Ephrin-A4 分子背景

Ephrin-A4 (EFNA4) is also known as EPH-related receptor tyrosine kinase ligand 4 (LERK4), EPLG4, which belongs to the ephrin family. EFNA4 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA4 is cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA4 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA4 may play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.

Ephrin-A4 参考文献

Ephrin-A4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PF-0667263 PF-06647263; PF-0667263; PF-6647263 临床一期 辉瑞 实体瘤 详情

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