登录 | 注册    关注公众号  
微信公众号
搜索
 > 【E-Cadherin】

E-Cadherin信息

英文名称:Cadherin-1
中文名称:钙粘蛋白-1
靶点别称:CAM 120/80,Epithelial cadherin,Ecad,Uvomorulin,CDHE,UVO
上市药物数量:0
临床药物数量:0
最高研发阶段:临床前

E-Cadherin产品列表

产品库
物种
标签
属性
ACRO质量管理体系
 
评论(0)
 

E-Cadherin分子别名

Cadherin-1,CDH1,CD324,E-cadherin,Arc-1,ECAD,LCAM,UVO

E-Cadherin分子背景

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

消息提示

请输入您的联系方式,再点击提交!

确定