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 > 【Dkk-3】重组蛋白信息

Dkk-3信息

英文名称:Dickkopf-related protein 3
中文名称:Dickkopf相关蛋白3
靶点别称:hDkk-3,REIC,Dickkopf-3,DKK3,Dkk-3
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Dkk-3产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
DK3-M5226
Mouse
Mouse Dkk-3 Protein, His Tag
DK3-H5220
Human
Human Dkk-3 Protein, His Tag

Dkk-3 分子别名

DKK3,REIC,RIG

Dkk-3 分子背景

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 参考文献

Dkk-3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
REIC gene therapy (Momotaro-Gene) Ad5-SGE-REIC/Dkk-3; MTG-201 临床二期 Momotaro-Gene, Icahn School of Medicine at Mount Sinai 前列腺癌 详情

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