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Complement Factor D信息

英文名称:Complement Factor D
中文名称:补体因子D
靶点别称:Complement factor D,PFD,Properdin factor D,DF ,CFD,C3 convertase activator,Adipsin
上市药物数量:0
临床药物数量:5
最高研发阶段:临床三期

Complement Factor D Molecule Synonym Name

CFD,Adipsin,PFD,DF,Complement factor D

Complement Factor D 分子背景

Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.

Complement Factor D 参考文献

Complement Factor D临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Lampalizumab RG-7417; RO-5490249; FCFD-4514S; TNX-234,RG7417,RO5490249 临床三期 基因泰克 年龄相关性黄斑变性 详情
ACH-5228 ACH-5228; ACH-0145228 临床二期 Achillion Pharmaceutical 阵发性睡眠性血红蛋白尿症 详情
ACH-5548 ACH-0145548; ACH-5548 临床一期 Achillion Pharmaceutical 自身免疫疾病
BCX-9930 BCX-9930 临床二期 BioCryst 阵发性睡眠性血红蛋白尿症 详情
Danicopan ACH-4471; ACH-0144471 临床三期 Achillion Pharmaceutical 阵发性睡眠性血红蛋白尿症 详情

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