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Coagulation Factor II信息

英文名称:Prothrombin
中文名称:凝血酶原
靶点别称:Thrombin light chain,Prothrombin,Thrombin heavy chain,Activation peptide fragment 2,F2,Activation peptide fragment 1,Coagulation factor II
上市药物数量:36
临床药物数量:61
最高研发阶段:批准上市

Coagulation Factor II产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
THN-H52H0
Human
Recombinant Human Coagulation Factor II / Thrombin Protein

Coagulation Factor II 分子别名

thrombin,Coagulation factor II

Coagulation Factor II 分子背景

Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing.

Coagulation Factor II 参考文献

Coagulation Factor II上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Human prothrombin complex (Tonrol Biopharmaceuticals) 人凝血酶原复合物(同路生物) 批准上市 同路生物 凝血因子X缺乏症, 血友病B, 先天性凝血因子VII缺乏症, 出血
Enoxaparin sodium biosimilar (Gland Pharma) 批准上市 Gland Pharma 不稳定型心绞痛, 深静脉血栓, 静脉血栓栓塞, 心肌梗塞
Thrombomodulin Alfa ART-123; TMD-123; AT-908,ART123 批准上市 旭化成 Thrombomodulin Alfa 日本 弥散性血管内凝血 旭化成 2008-01-25 00:00:00.0 弥散性血管内凝血 详情
Fibrin patch (Ethicon/Omrix Biopharmaceuticals) 批准上市 强生 human fibrinogen / human thrombin ema

 Supportive treatment in adult surgery where standard surgical techniques are insufficient (see section 5.1):

-   for improvement of haemostasis.

Omrix Biopharmaceuticals N. V. 2013-09-25 出血 详情
Dermatan sulfate 硫酸皮肤素 MF-701,MF-777 批准上市 Mediolanum Farmaceutici Dermatan sulfate 意大利 血栓, 静脉血栓栓塞, 血小板减少症 Mediolanum Farmaceutici 1998-07-01 00:00:00.0 血小板减少症, 静脉血栓栓塞, 血栓
Hirudin biosimilar (Rhein-Minapharm) 批准上市 Rhein Minapharm Biogenetics 深静脉血栓 详情
Argatroban 阿加曲班 DK-7419; GN1600; MCI-9038; MD-805; MDI-805; OM-805,MD-805,OM-805,DK-7419,MCI-9038,MQPA 批准上市 田边三菱制药, 辉瑞 Argatroban 日本 1990-01-01 00:00:00.0 经皮冠状动脉介入治疗, 血小板减少症 详情
Human fibrinogen/Human thrombin (Instituto Grifols) 批准上市 Grifols human fibrinogen;human thrombin ema

Supportive treatment where standard surgical techniques are insufficient for improvement of haemostasis.

Raplixa must be used in combination with an approved gelatin sponge.

Raplixa is indicated in adu

Mallinckrodt Pharmaceuticals Ireland Limited 2015-03-19 出血
Antithrombin Gamma 抗凝血酶γ KW-3357,KW3357 批准上市 协和发酵麒麟 Antithrombin Gamma 日本 遗传性抗凝血酶缺乏症, 弥散性血管内凝血 协和发酵麒麟 2015-07-03 00:00:00.0 弥散性血管内凝血, 遗传性抗凝血酶缺乏症 详情
Antithrombin III (CSL Behring) BI51.017 批准上市 CSL Behring Antithrombin III (CSL Behring) 日本 血栓, 弥散性血管内凝血 CSL Behring 1987-08-02 00:00:00.0 弥散性血管内凝血, 血栓, 血栓 详情
Human fibrinogen concentrate (CSL Behring) 批准上市 CSL Behring 纤维蛋白原血症 详情
Enoxaparin sodium biosimilar (Sahar International Trading) 批准上市 Sahar International Trading 不稳定型心绞痛, ST段抬高心肌梗死(STEMI), 静脉血栓栓塞, 凝血障碍
Fibrin sealant patch (Takeda) 批准上市 奈科明制药, 武田 human fibrinogen;human thrombin ema

TachoSil is indicated in adults for supportive treatment in surgery for improvement of haemostasis, to promote tissue sealing, for suture support in vascular surgery where standard techniques are insufficient

Takeda Austria GmbH 2004-06-08 出血 详情
Andexanet alfa PRT-064445; PRT-4445; PRT-44545,PRT064445,PRT4445 批准上市 Portola Pharmaceutical 出血紊乱 详情
Enoxaparin sodium biosimilar (Harvest Moon Pharmaceuticals) 依诺肝素钠生物类似物(Harvest Moon Pharmaceuticals) 批准上市 Harvest Moon 不稳定型心绞痛, 深静脉血栓, 静脉血栓栓塞, 心肌梗塞
Enoxaparin sodium biosimilar (Chandra Bhagat Pharma) 批准上市 Chandra Bhagat Pharma(CBC) 深静脉血栓
Desirudin 地西卢定 CGP-39393; r-Hirudin 批准上市 未知 desirudin ema

Prevention of deep venous thrombosis in patients undergoing elective hip or knee replacement surgery.

Canyon Pharmaceuticals Ltd. 1997-07-09 静脉血栓栓塞 详情
Human fibrinogen concentrate (LFB Biomedicaments) FGTW; FibCLOT 批准上市 LFB Biotechnologies, Innsbruck Medical University FibCLOT hma 纤维蛋白原血症, 凝血障碍 Laboratoire Francais du Fractionnement et des Biotechnologies
3 Avenue des Tropiques
ZA de Courtaboeuf
91940 Les Ulis, France
2015-12-22 纤维蛋白原血症, 凝血障碍 详情
Enoxaparin Sodium 依诺肝素钠 PK-10169; RP-54563; XRP-4563K; M-enoxaparin; PRY-005; RPY-005 批准上市 赛诺菲 LOVENOX (PRESERVATIVE FREE) fda SANOFI AVENTIS US 1993-03-29 不稳定型心绞痛, ST段抬高心肌梗死(STEMI), 静脉血栓栓塞 详情
Bivalirudin 比伐芦定 BG-8967,BG8967,BG 8967 批准上市 The Medicines Company ANGIOMAX fda 经皮冠状动脉介入治疗, 不稳定型心绞痛, 经皮腔内冠状动脉成形术 SANDOZ INC 2000-12-15 经皮冠状动脉介入治疗, 血小板减少症, 经皮腔内冠状动脉成形术, 血栓栓塞 详情
Liquid fibrin sealant (OMRIX Biopharmaceuticals) 批准上市 OMRIX Biopharmaceuticals, Ethicon human fibrinogen;human thrombin ema

Evicel is used as supportive treatment in surgery where standard surgical techniques are insufficient, for improvement of haemostasis.

Evicel is also indicated as suture support for haemostasis in vascular sur

Omrix Biopharmaceuticals N. V. 2008-10-05 出血 详情
Antithrombin III (Human, Grifols) 批准上市 Grifols 遗传性抗凝血酶缺乏症, 血栓栓塞 详情
Human coagulation factor X (Bio Products Laboratory) 批准上市 Bio Products Laboratory Human coagulation factor X ema

Coagadex is indicated for the treatment and prophylaxis of bleeding episodes and for perioperative management in patients with hereditary factor X deficiency. Coagadex is indicated in all age groups.

Bio Products Laboratory Limited 2016-03-16 凝血因子X缺乏症 详情
Human fibrinogen/Human thrombin (Mallinckrodt) PRO-0601 批准上市 Mallinckrodt 术后出血 详情
Enoxaparin sodium biosimilar (Blau Pharmaceuticals) 批准上市 Blau Pharmaceuticals 血栓
Human prothrombin complex concentrate (Guizhou Taibang Biological Products) 批准上市 贵州泰邦生物制品 凝血酶原复合体缺乏症
Prothrombin complex concentrate (Sanquin) 批准上市 Sanquin 出血 详情
Enoxaparin sodium biosimilar (PT Kalbe) 批准上市 Kalbe Farma 不稳定型心绞痛, 深静脉血栓, 心肌梗塞
Human prothrombin complex (Octapharma) 批准上市 Octapharma 德国 出血 Octapharma 2003-03-14 00:00:00.0 出血 详情
Enoxaparin sodium biosimilar (Rovi) 批准上市 Rovi 不稳定型心绞痛, 深静脉血栓, 心肌梗塞 详情
Antithrombin alfa rhATIII 批准上市 健赞, rEVO Biologics Antithrombin alfa ema

ATryn is indicated for the prophylaxis of venous thromboembolism in surgery of patients with congenital antithrombin deficiency. ATryn is normally given in association with heparin or low molecular weight heparin.

Laboratoire Francais du Fractionnement et des Biotechnologies 2006-07-28 遗传性抗凝血酶缺乏症 详情
Fibrinogen (Octapharma) 批准上市 Octapharma 纤维蛋白原血症 详情
Prothrombin complex concentrat (Taibang Biological Products) 人凝血酶原复合物(泰邦生物制品) 批准上市 山东泰邦生物制品 Human Prothrombin Complex cfda 出血 2014-09-30 出血
Idarucizumab BI-655075; 97RWB5S1U6 (UNII code) ,BI655075 批准上市 勃林格殷格翰 PRAXBIND fda 紧急手术, 出血 BOEHRINGER INGELHEIM 2015-10-16 紧急手术, 出血 详情
Enoxaparin sodium biosimilar (Neiss Labs) 批准上市 Neiss Labs 深静脉血栓
Dabigatran Etexilate Mesylate 达比加群酯甲磺酸盐 BIBR-1048MS; BIBR-953; BIBR-953-ZW; BIBR-1048,BIBR 1048 MS,BIBR1048 MS 批准上市 勃林格殷格翰 Dabigatran etexilate mesilate ema

Primary prevention of venous thromboembolic events in adult patients who have undergone elective total-hip-replacement surgery or total-knee-replacement surgery.

Prevention of stroke and systemic embolism in a

Boehringer Ingelheim International GmbH 2008-03-17 肺血管阻塞症, 深静脉血栓, 中风和全身性栓塞, 静脉血栓栓塞 详情

Coagulation Factor II临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
GH-9001 GH-9001 临床一期 InflaZyme, 利奥制药 血栓
Efegatran sulfate hydrate GYKI-14766; LY-294468 临床二期 礼来, Ivax 血栓, 心肌梗塞
VE-1902 VE-1902 临床一期 Verseon 心血管疾病, 中风, 急性冠脉综合征, 房颤卒中, 静脉血栓栓塞
Ximelagatran H-376/95; H-376; H-37695,H 376/95,H376/95 撤市 阿斯利康 静脉血栓栓塞 详情
Recombinant Hirudin-2 (AMMS) 临床申请 军事医学科学院放射医学研究所 不明
L-376062 L-372236; L-377009; L-376062; L-375378; L-373722; L-372460 临床一期 默沙东 血栓
TRI-50b TRI-50b; TRI-50; TRI-B50,TRI50b 临床二期 Trigen Holdings AG 血栓
Napsagatran RO-466240; RO-46-6240/010 临床二期 罗氏 血栓, 心肌梗塞
Flovagatran sodium TGN-255,TGN255 临床二期 Trigen Holdings AG 血栓
BCH-2763 BCH-2763 临床前 Shire 血栓
Sofigatran MCC-977 临床二期 田边三菱制药 深静脉血栓
DP-4088 DPOC-4088; DP-4088,DP4088,DPOC4088 临床一期 默沙东, Diakron, Orchid 凝血障碍 详情
Recombinant human thrombin (Suzhou Zelgen Biopharmaceutical) 临床二期 泽璟生物 术后出血
Recombinant bifunctional hirudin (Fudan University) 临床一期 复旦大学 不明
CTB-001 CTB-001; CT-001,CTB-001 临床一期 C-TRI 血栓 详情
Vasoflux 临床二期 InflaZyme 心肌梗塞, 血栓
LB-30057 CI-1028; LB-30057; PD-172524 临床一期 LG化学, 辉瑞 血栓
UK-156406 UK-156406 临床一期 辉瑞 血栓
GW-473178 GW-473178 临床一期 葛兰素史克 静脉血栓栓塞, 心房颤动
Enoxaparin sodium biosimilar (Techdow) Inhixa BLA 申请 深圳天道医药 不稳定型心绞痛, 深静脉血栓, 静脉血栓栓塞, 心肌梗塞
SR-123781 SR-123781; SR-123781A; SanOrg-123781; HDS; SANORG 123781A 临床三期 赛诺菲 急性冠脉综合征, 血栓 详情
PF-05230907 PF-05230907; PF-5230907; PF-907 临床一期 辉瑞 脑出血 详情
CX-397 CX-397 临床二期 科研制药株式会社 弥散性血管内凝血, 血栓
Ichorcumab JNJ-64179375 临床二期 杨森, 强生 血栓 详情
EP-217609 Org-217609; EP-217609,Org217609,EP21796,EP217609C101 临床二期 默沙东, Endotis 血栓
ORG-27306 ORG-27306 临床一期 默沙东 血栓
V-19 V-19 临床二期 InflaZyme 血栓
TRIB-50 TRI-50; TRI-B50 临床二期 Thrombosis Research Institute, Trigen Holdings AG 血栓
Org-36764 Org-36764 临床一期 默沙东 血栓
Odiparcil 424323; SB-424323;IVA-336,SB424323 临床二期 艾伯维, 葛兰素史克 VI型黏多糖贮积症 详情
Deligoparin sodium OP-2000 临床三期 Opocrin SpA, Aeolus Pharmaceuticals, Perrigo 心血管疾病, 溃疡性结肠炎, 炎症性肠病 详情
Thrombomodulin (Mochida/JCR) MB-015; MR-33; TMD1-105; rhu-TM BLA 申请 持田制药, JCR Pharmaceuticals 弥散性血管内凝血
Peptide-based blood coagulant (Haemostatix) 临床二期 Haemostatix, Boryung Pharmaceutical 术后出血 详情
BSF-208791 BSF 208791; BSF208791 临床一期 艾伯维 血栓
rHV2-Lys-47 rHV2-Lys-47 临床一期 赛诺菲, Transgene 弥散性血管内凝血, 血栓
EGR-Xa EGR-Xa 临床一期 COR Therapeutics Inc 血栓栓塞
SSR-182289A SSR-182289A; SSR-182289,SSR182289A,SSR182289 临床二期 赛诺菲 血栓
CVS-1578 CVS-1578 临床一期 默沙东, Dendreon Corporation 血栓栓塞
Enoxaparin sodium biosimilar (Pharmathen) Thorinane BLA 申请 Pharmathen 不稳定型心绞痛, 深静脉血栓, 静脉血栓栓塞, 心肌梗塞
Targeted NIF-hirulog hybrid (Chongqing Fujin Biomedical) 临床一期 重庆富进生物医药 脑血管疾病
Neutrophil inhibitory factor-hirulog hybrid rNIF-hirulog; TNHH 临床一期 重庆其生物制药, 四川大学华西医院 中风
Heparinase I 临床三期 IBEX Technologies, BioMarin Pharmaceutical 凝血障碍
Semuloparin sodium AVE-5026 NDA 申请 赛诺菲 血栓栓塞 详情
ARC-183 ARC-183 临床一期 Archemix 血栓
AZD-8165 AZD-8165 临床一期 阿斯利康 血栓 详情
Human prothrombin complex concentrate (Shanxi Kangbao Biological Products) 临床阶段不明 山西康宝生物 术后出血, 出血
MPC-0920 MPC-0920 临床一期 Myriad Genetics 血栓
CVS-1123 CVS-1123 临床一期 默沙东 不稳定型心绞痛, 冠状动脉疾病, 静脉血栓栓塞
Recombinant hirudin (Kerun Biopharmaceutical) 临床申请 重庆科润生物医药 血栓
EP-42675 Org-42675; EP-42675,EP42675,Org42675 临床一期 默沙东, Endotis 血栓
3DP-4815 3DP-4815; JNJ-6368661; RWJ-422521; TDP-4815 临床一期 强生 动脉血栓, 静脉血栓栓塞
Enoxaparin sodium biosimilar (Biocad) BCD-080 临床三期 Biocad 深静脉血栓, 静脉血栓栓塞 详情
Recombinant staphylokinase-hirudin fusion protein 临床申请 人福医药, 军事医学科学院放射医学研究所 血栓栓塞
S-18326 S-18326 临床一期 施维雅 血栓
NU-172 ARC-2172; NU-172 临床一期 Archemix, 方舟生物医药 血栓 详情
Inogatran Inogatran; H-314/27; HA-31427 临床二期 阿斯利康 不稳定型心绞痛, 心肌梗塞
EH 临床一期 军事医学科学院, 北京三有利和泽生物科技 深静脉血栓
RWJ-27755 PPACK; RWJ-27755 临床前 强生 血栓
CJC-1004 CJC-1004; CCI-1004; DAC:T1 临床二期 ConjuChem 血栓
MER-102 临床一期 Merrion Pharmaceuticals 血栓
Adomiparin sodium M-118 临床二期 Momenta 急性冠脉综合征 详情

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