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CD27 Ligand信息

英文名称:CD70 antigen
中文名称:CD70抗原
靶点别称:CD27-L,Tumor necrosis factor ligand superfamily member 7,CD70,CD27L,CD27LG,TNFSF7,CD27 ligand
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

CD27 Ligand 分子别名

CD70,CD27LG,TNFSF7,TNFSF7G,CD27L

CD27 Ligand 分子背景

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

CD27 Ligand 参考文献

CD27 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AMG-172 AMG-172 临床一期 安进 肾癌 详情
MDX-1411 MDX-1411 临床一期 Medarex 肾癌 详情
SGN-CD70A SGN-CD70A; SGN-70A; SGNCD-70A 临床一期 Seattle Genetics 非霍奇金淋巴瘤, 肾癌 详情
Vorsetuzumab mafodotin SGN-75 临床一期 Seattle Genetics 非霍奇金淋巴瘤, 肾癌 详情
Anti-CD70 CAR T cell therapy (Allogene Therapeutics) 临床前 Allogene Therapeutics 肾细胞癌, 非霍奇金淋巴瘤
Cusatuzumab ARGX-110 临床二期 arGEN-X, 杨森 骨髓增生异常综合征, 鼻咽癌, 皮肤T细胞淋巴瘤, 血液系统恶性肿瘤, 实体瘤, 急性骨髓性白血病 详情
Vorsetuzumab SGN-70,SGN70 临床一期 Seattle Genetics 斑块状银屑病, 自身免疫疾病, 炎症, 癌症
MDX-1203 MDX-1203; BMS-936561 临床一期 百时美施贵宝 非霍奇金B细胞淋巴瘤, 肾癌 详情

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