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CD200信息

英文名称:OX-2 membrane glycoprotein
中文名称:OX-2膜糖蛋白
靶点别称:OX-2 membrane glycoprotein,MOX1 ,MOX2,CD200,CD_antigen=CD200
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

CD200 Molecule Synonym Name

CD200,MOX1,MOX2,MRC,OX-2,My033

CD200 分子背景

CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

CD200 参考文献

CD200临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Samalizumab ALXN-6000 临床二期 亚力兄制药, The Leukemia & Lymphoma Society 急性骨髓性白血病 详情

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