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CD2信息

英文名称:T-cell surface antigen CD2
中文名称:T细胞表面抗原CD2
靶点别称:T11,T-Cell Surface Antigen CD2,LFA-2,CD2 Antigens,CD2,LFA-3 Receptor,CD2 Molecule,Rosette Receptor,SRBC,CD2 Antigen,CD2 Antigen (P50), Sheep Red Blood Cell Receptor,T-Cell Surface Antigen T11/Leu-5,Lymphocyte-Function Antigen-2,Erythrocyte Receptor
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

CD2分子别名

CD2,SRBC,LFA-2,T11

CD2分子背景

T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

CD2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Siplizumab MEDI-507; TCD-601 临床二期 Catholic University Of Louvain, Itb-Med Llc 肾脏移植排斥, 一型糖尿病, 白血病, 肾功能不全, 肝脏移植排斥, 肿瘤, 骨髓增生异常综合征, 肾脏疾病, 移植物抗宿主病, 多发性骨髓瘤, 银屑病, T-细胞淋巴瘤, 化脓性汗腺炎, 淋巴瘤, 镰状细胞血症, 终末期肾脏病 详情
Alefacept LFA-3-TIP; LFA-3(92)IgG; BG-9273; BG-9712; ASP-0485 临床一期 安斯泰来制药集团 一型糖尿病, 移植物抗宿主病, 银屑病, 再生障碍性贫血, 淋巴瘤 详情
SBT-11-5301 SBT115301 临床一期 Sonoma Biotherapeutics Inc 自身免疫疾病 详情
PIT-565 PIT-565 临床一期 诺华制药 B-细胞淋巴瘤, 前体B-细胞成淋巴细胞白血病-淋巴瘤, 系统性红斑狼疮, 急性髓细胞样白血病 详情

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