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CD2信息

英文名称:T-cell surface antigen CD2
中文名称:T细胞表面抗原CD2
靶点别称:LFA-2,Rosette receptor,SRBC,CD2,T-cell surface antigen CD2,CD_antigen=CD2,Erythrocyte receptor,LFA-3 receptor,T-cell surface antigen T11/Leu-5
上市药物数量:0
临床药物数量:3
最高研发阶段:撤市

CD2产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CD2-H5226
Human
Human CD2 / SRBC Protein, His Tag
CD2-H5258
Human
Human CD2 / SRBC Protein, Fc Tag
 
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CD2 Molecule Synonym Name

CD2,SRBC,LFA-2,T11

CD2 分子背景

T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

CD2 参考文献

CD2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Siplizumab MEDI-507 临床二期 Catholic University of Louvain, MedImmune 皮肤T细胞淋巴瘤, 银屑病, 移植物抗宿主病, 银屑病关节炎, 类风湿性关节炎, 外周T细胞淋巴瘤, 肾移植排斥反应 详情
Alefacept ASP-0485; BG-9273; BG-9712; LFA-3(92)IgG; LFA-3-TIP 撤市 安斯泰来 银屑病 详情
BTI 322 BTI-322 临床二期 University of Leuven, MedImmune 自身免疫疾病, 移植物抗宿主病, 肝脏移植排斥反应, 肾移植排斥反应

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