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B7-H3信息

英文名称:CD276 antigen
中文名称:CD276抗原
靶点别称:Costimulatory molecule,4Ig-B7-H3,B7 homolog 3,B7H3,B7-H3,CD276
上市药物数量:0
临床药物数量:6
最高研发阶段:临床二期

B7-H3产品列表

B7-H3 分子别名

B7-H3,CD276,B7 homolog 3

B7-H3 分子背景

B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.

B7-H3 参考文献

B7-H3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Monoclonal antibody 8H9 I-131 131-I-8H9; 8H9-MAb; 131I-8H9-(B7-H3) 临床二期 斯隆-凯特琳癌症中心, Y-mAbs 中枢神经系统囊虫病, 腹膜癌 详情
DS-5573 DS-5573; DS-5573a 临床一期 第一三共 实体瘤 详情
Enoblituzumab MGA-271,MGA271 临床二期 MacroGenics 前列腺癌 详情
Monoclonal antibody 8H9 I-124 124I-8H9; 124I-8H9-(B7-H3) 临床二期 斯隆-凯特琳癌症中心, Weill Cornell Medical College 神经胶质瘤
MGC-018 MGC-018 临床二期 MacroGenics 实体瘤
Orlotamab MGD-009; B7-H3 x CD3 临床一期 MacroGenics 实体瘤 详情

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