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 > 【Angiopoietin-like 3】重组蛋白信息

Angiopoietin-like 3产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
AN3-H5226
Human
Recombinant Human Angiopoietin-like 3 / ANGPTL3 Protein

Angiopoietin-like 3 分子别名

ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

Angiopoietin-like 3 分子背景

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

Angiopoietin-like 3 参考文献

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