登录 | 注册    关注公众号  
微信公众号
搜索
 > 【Alpha-endosulfine】

Alpha-endosulfine产品咨询

* 此表格只用于收集产品需求咨询,所有信息将严格保密。
                   
ACRO质量管理体系
 
评论(0)
 

Alpha-endosulfine 分子别名

ENSA,Alpha-endosulfine,ARPP-19e,endosulfine Alpha

Alpha-endosulfine 分子背景

Alpha-endosulfine (ENSA),a member of the endosulfine family, is also known as ARPP-19e,which is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. ENSA is a protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, ENSA is able to specifically interact with PPP2R2D (PR55-delta) and inhibit its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). ENSA acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

Alpha-endosulfine 前沿进展

消息提示

请输入您的联系方式,再点击提交!

确定