IL-4 R alpha 分子别名
IL-4 R alpha 分子背景
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).
Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1.
IL-4 R alpha 参考文献
- Ikizawa K., et al., 2000, Biochem Biophys Res Commun, 268(1):54-9.
- Kashiwada M., et al., 2001, J Immunol, 167(11):6382-7.
- Hage T., et al., 1999, Cell 97 (2): 271–81.
- Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307.
- WillsKarp, M., F.D. Finkelman, 2008, Sci. Signal. 1:pe55.
- Tundup S., 2012, Ann. N. Y. Acad. Sci., 1253: E1–E13.
- Ikizawa K, Yanagihara Y., 2000, Biochem. Biophys. Res. Commun., 268 (1): 54–9.
- Kashiwada M., 2001, J. Immunol., 167 (11): 6382–7.