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 > 【IL-6 R alpha】重组蛋白信息

IL-6 R alpha产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
ILR-H4223
Human
Human IL-6 R alpha / CD126 Protein, His Tag
CD6-H82E8
Human
Biotinylated Human IL-6 R alpha / CD126 Protein, Avitag,His Tag
ILR-H5259
Human
Human IL-6 R alpha / CD126 Protein, Fc Tag

IL-6 R alpha 分子别名

IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80

IL-6 R alpha 分子背景

Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

IL-6 R alpha 参考文献

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