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Fas Ligand信息

英文名称:Soluble Fas ligand
中文名称:可溶性Fas配体
靶点别称:TNFSF6,Fas antigen ligand,CD_antigen=CD178,Apoptosis antigen ligand,sFasL,APT1LG1 ,FASLG,Tumor necrosis factor ligand superfamily member 6,CD95-L,FasL intracellular domain,CD95 ligand,Soluble Fas ligand,Receptor-binding FasL ectodomain,Fas ligand,CD95L,Fa
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

Fas Ligand产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
FAL-H5241
Human
Human Fas Ligand / TNFSF6 Protein, His Tag

Fas Ligand 分子别名

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Fas Ligand 分子背景

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Fas Ligand 参考文献

Fas Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Fasaret AP-300 临床三期 ApopLogic 实体瘤
Asunercept CAN-008; APG-101,CAN008; APG101 临床二期 Apogenix, 北海康成 骨髓增生异常综合征, 成胶质细胞瘤 详情

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