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Dkk-1信息

英文名称:Dickkopf-related protein 1
中文名称:Dickkopf相关蛋白-1
靶点别称:hDkk-1,Dickkopf-1,DKK1,SK,Dkk-1,Dickkopf-related protein 1
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

Dkk-1产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
DK1-H5221
Human
Human Dkk-1 Protein, His Tag
DK1-H5258
Human
Human Dkk-1 Protein, Fc Tag
DK1-H5286
Human
Human Dkk-1 Protein, Strep Tag
DK1-M52H6
Mouse
Mouse Dkk-1 Protein, His Tag
DK1-H82F5
Human
Biotinylated Human Dkk-1 Protein, Fc,Avitag

Dkk-1 分子别名

DKK1,SK

Dkk-1 分子背景

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

Dkk-1 参考文献

Dkk-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
DKN-01 DKN-01; LY-2812176 临床二期 礼来, Leap Therapeutics 非小细胞肺癌, 食道癌, 实体瘤, 多发性骨髓瘤, 胆道癌 详情
Mab-B3 Mab-B3 临床一期 礼来 骨疾病
Recombinant human R-spondin 1 NU-206; R-Spondin-1; RSpo-1 临床一期 方舟生物医药, 协和发酵麒麟 外伤, 骨疾病, 粘膜炎, 炎症性肠病
BHQ-880 BHQ-880; MOR-4910 临床二期 MorphoSys, 诺华 实体瘤, 多发性骨髓瘤 详情

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