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C-Reactive Protein信息

英文名称:C-reactive protein
中文名称:C-反应蛋白
靶点别称:PTX1,CRP
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

C-Reactive Protein产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
CRP-H5226
Human
Human C-Reactive Protein (CRP) Protein, His Tag

C-Reactive Protein 分子别名

CRP,C-reactive Protein

C-Reactive Protein 分子背景

C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

C-Reactive Protein 参考文献

C-Reactive Protein临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AZ-175 AZ-175; AZ-121 临床阶段不明 新墨西哥大学, AZANO biotech 红斑狼疮性肾炎, 免疫性血小板减少性紫癜
ISIS-329993 ISIS-329993; ISIS-CRPRx; ISIS-CRP 临床二期 Ionis Pharmaceuticals 心房颤动 详情
ISIS-353512 ISIS-353512 临床一期 Ionis Pharmaceuticals, Korea Institute of Science and Technology 心血管疾病, 肾脏疾病, 炎症, 类风湿性关节炎, 克罗恩氏病 详情
IB-RA (Innobioscience LLC) IB-RA 临床二期 Innobioscience LLC 类风湿性关节炎
GLI-8545 GLI-8545,GLI 8545,GLI8545 临床阶段不明 Galileo Pharmaceuticals 肾衰竭

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