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Carbonic Anhydrase II信息

英文名称:Carbonic anhydrase II
中文名称:碳酸酐酶II
靶点别称:CAC,CA-II,Carbonic anhydrase C,Carbonate dehydratase II,Carbonic anhydrase II,CA2,Carbonic anhydrase 2
上市药物数量:8
临床药物数量:3
最高研发阶段:批准上市

Carbonic Anhydrase II产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
CA2-H5123
Human
Human Carbonic Anhydrase II / CA2 Protein, His Tag
CA2-H5228
Human
Human Carbonic Anhydrase II / CA2 Protein, His Tag
 
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Carbonic Anhydrase II 分子别名

CA2,CA-II,CAII,Car2

Carbonic Anhydrase II 分子背景

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes. CAs form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs rather slowly in the absence of a catalyst. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. The active site of most carbonic anhydrases contains a zinc ion. They are, therefore, classified as metalloenzymes. There are at least five distinct CA families (α, β, γ, δ and ε). These families have no significant amino acid sequence similarity and in most cases are thought to be an example of convergent evolution. The α-CAs are found in humans. Carbonic anhydrase II (CA2) is also known as Carbonate dehydratase II, Carbonic anhydrase C, is one of fourteen forms of human α carbonic anhydrases. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Renal carbonic anhydrase allows the reabsorption of sodium ions in the proximal tubule. Carbonic anhydrase II has been shown to interact with Band 3 and Sodium-hydrogen antiporter 1.

Carbonic Anhydrase II 参考文献

Carbonic Anhydrase II上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Brinzolamide/Timolol Maleate 布林佐胺/马来酸噻吗洛尔 批准上市 爱尔康 brinzolamide;timolol maleate ema

Decrease of intraocular pressure (IOP) in adult patients with open angle glaucoma or ocular hypertension for whom monotherapy provides insufficient IOP reduction.

Novartis Europharm Limited 2008-11-25 高眼压症, 开角型青光眼, 青光眼 详情
Brinzolamide/Brimonidine Tartrate 布林佐胺/酒石酸溴莫尼定 批准上市 诺华 SIMBRINZA fda NOVARTIS 2013-04-19 高眼压症, 开角型青光眼 详情
Methazolamide 醋甲唑胺 VVP-808 批准上市 未知 NEPTAZANE fda LEDERLE 1959-01-26 青光眼 详情
Brinzolamide 布林佐胺 AL-4862; ALO-4862 批准上市 爱尔康 AZOPT fda 高眼压症, 开角型青光眼 NOVARTIS 1998-04-01 高眼压症, 开角型青光眼 详情
Dorzolamide Hydrochloride/Timolol Maleate/Brimonidine Tartrate 盐酸多佐胺/马来酸噻吗洛尔/酒石酸溴莫尼定 PRO-122 批准上市 Laboratorios Sophia 高眼压症, 青光眼 详情
Topiramate 托吡酯 McN-4853; RWJ-17021; TPM; W-6485; KW-6485P; SPN-538 批准上市 杨森 Topiramate 英国 偏头痛, 癫痫 杨森 1995-01-01 00:00:00.0 偏头痛, 癫痫 详情
Phentermine Hydrochloride/Topiramate 盐酸芬特明/托吡酯 VI-0521 批准上市 Vivus QSYMIA fda VIVUS 2012-07-17 肥胖症 详情
Sultiame 舒噻美 Riker-594 批准上市 未知 Sultiam-neuraxpharm 100 mg Filmtabletten hma 癫痫 neuraxpharm Arzneimittel GmbH
Elisabeth-Selbert-Str. 23
D-40764 Langenfeld
Germany
2016-11-18 癫痫 详情

Carbonic Anhydrase II临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Brinzolamide/Travoprost 临床三期 爱尔康 高眼压症, 青光眼 详情
Ondansetron/Topiramate 临床二期 ADial Pharmaceuticals 酒精中毒
Para-Toluenesulfonamide PTS-100; PTS-02; PTS-302; PTS-500; p-TSA; PTS NDA 申请 北京健达康, 共信医药科技股份有限公司, 天津红日药业, 红日健达康 腺样囊性癌, 非小细胞肺癌, 肝细胞癌 详情

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