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 > 【beta 2-Microglobulin】重组蛋白信息

beta 2-Microglobulin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
B2M-C5226
Cynomolgus / Rhesus macaque
Cynomolgus / Rhesus macaque beta 2-Microglobulin / B2M Protein, His Tag
B2M-H5225
Human
Human beta 2-Microglobulin / B2M Protein, His Tag
B2M-R5229
Rat
Rat beta 2-Microglobulin / B2M Protein, His Tag

beta 2-Microglobulin 分子别名

B2M

beta 2-Microglobulin 分子背景

β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).

beta 2-Microglobulin 参考文献

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