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TIGIT信息

英文名称:T cell immunoglobulin and ITIM domains
中文名称:T细胞免疫球蛋白ITIM结构域
靶点别称:VSTM3,V-set and transmembrane domain-containing protein 3,VSIG9,V-set and immunoglobulin domain-containing protein 9,TIGIT
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

TIGIT产品列表

TIGIT Molecule Synonym Name

TIGIT,VSIG9,VSTM3

TIGIT 分子背景

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

TIGIT 参考文献

TIGIT临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tiragolumab MTIG-7192A; RG-6058; RO-7092284 临床一期 基因泰克 实体瘤 详情
AB-154 AB-154 临床一期 Arcus Biosciences 实体瘤, 血液癌症 详情
BMS-986207 (Bristol-Myers Squibb) BMS-986207 临床二期 百时美施贵宝, 小野制药 实体瘤
MK-7684 MK-7684; MK7684 临床一期 默沙东 实体瘤 详情

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