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TFPI信息

英文名称:Tissue factor pathway inhibitor
中文名称:组织因子通道抑制剂
靶点别称:Lipoprotein-associated coagulation inhibitor,TFPI,LACI,Extrinsic pathway inhibitor,EPI,TFPI1
上市药物数量:0
临床药物数量:2
最高研发阶段:临床三期

TFPI产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
TFI-H8226
Human
Biotinylated Human TFPI Protein, His Tag, ultra sensitivity (primary amine labeling)
TFI-H5226
Human
Human TFPI Protein, His Tag
TFI-C52H3
Rhesus macaque
Rhesus macaque TFPI Protein, His Tag
 
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TFPI 分子别名

TFPI,LACI,TFPI1,EPI,TFI

TFPI 分子背景

Tissue factor pathway inhibitor (TFPI) is also known as Extrinsic pathway inhibitor (EPI), Lipoprotein - associated coagulation inhibitor (LACI), is a plasma proteinase inhibitor synthesized by vascular endothelial cells and part of it is associated with glycosaminoglycans of these cells. TFPI is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa) and Thrombin (Factor IIa). TFPI is a secreted protein with a N­terminal acidic region, three Kunitz (K) domains separated with by two linker regions, and a C­terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF); The second K domain inhibits factor Xa; The third K domain binds to heparin; The C­terminal basic region may have several functions. For example, it plays an important role in binding of TFPI to cell surfaces.

TFPI 参考文献

TFPI临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Concizumab mAb-2021; NN-7415; NNC-0172-0000-2021; NNC-0172-2021; NNC-172-2021; mAbTFPI2021 ; Anti-TFPI,mAb2021; NN7415; NNC0172-0000-2021; NNC0172-2021; NNC172-2021; mAb-TFPI2021  临床三期 诺和诺德 血友病A, 血友病B 详情
BAY-1093884 BAY-109; BAY-1093884,BAY1093884 临床二期 拜耳, MorphoSys 血友病 详情

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