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Mouse gp130 / CD130 / IL-6 R beta Protein, His Tag

分子别名(Synonym)

IL6ST,gp130,CD130,IL-6RB,IL-6R-beta,CDw130

表达区间及表达系统(Source)

Mouse gp130, His Tag (ILT-M52H1) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Glu 617 (Accession # NP_034690).

Predicted N-terminus: Gln 23

蛋白结构(Molecular Characterization)

Online(Gln 23 - Glu 617) NP_034690

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 68.5 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse gp130, His Tag (Cat. No. ILT-M52H1) SDS-PAGE gel

Mouse gp130, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

 

前沿进展

 
货号/价格

ILT-M52H1-100ug / ¥2900

ILT-M52H1-1mg (500ug X 2) / ¥18000

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gp130靶点信息
英文全称:Interleukin-6 receptor subunit beta
中文全称:白细胞介素-6β亚基
种类:Homo sapiens
上市药物数量:2详情
临床药物数量:17详情
最高研发阶段:批准上市
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