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Human VSIG4 Protein, His Tag

分子别名(Synonym)

VSIG4,CRIg,Z39IG

表达区间及表达系统(Source)

Human VSIG4, His Tag (VS4-H5226) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 283 (Accession # AAH10525).

Predicted N-terminus: Arg 20

蛋白结构(Molecular Characterization)

Online(Arg 20 - Pro 283) AAH10525

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 30.1 kDa. The protein migrates as 35-47 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human VSIG4, His Tag (Cat. No. VS4-H5226) SDS-PAGE gel

Human VSIG4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.

 

前沿进展

 
货号/价格

VS4-H5226-100ug / ¥2500

VS4-H5226-1mg / ¥14400

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