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Human TDGF1 / Cripto Protein, Fc Tag

分子别名(Synonym)

TDGF1,CRGF,CRIPTO

表达区间及表达系统(Source)

Human TDGF1, Fc Tag (CRO-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 31 - Thr 172 (Accession # P13385-1).

Predicted N-terminus: Leu 31

蛋白结构(Molecular Characterization)

Online(Leu 31 - Thr 172) P13385-1

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 42.6 kDa. The protein migrates as 44-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human TDGF1, Fc Tag (Cat. No. CRO-H5253) SDS-PAGE gel

Human TDGF1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

 

前沿进展

 
货号/价格

CRO-H5253-50ug / ¥2900

CRO-H5253-1mg / ¥18000

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TDGF1靶点信息
英文全称:Teratocarcinoma-derived growth factor 1
中文全称:畸胎瘤衍生生长因子-1
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床一期
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