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Human PTH1R / PTHR1 Protein, His Tag

分子别名(Synonym)

PTH1R,PTHR,PTHR1

表达区间及表达系统(Source)

Human PTH1R, His Tag (PTR-H5222) is expressed from human 293 cells (HEK293). It contains AA Asp 27 - Gly 188 (Accession # Q03431-1).

Predicted N-terminus: Asp 27

蛋白结构(Molecular Characterization)

Online(Asp 27 - Gly 188) Q03431-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 19.6 kDa. The protein migrates as 27-43 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>85% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human PTH1R, His Tag (Cat. No. PTR-H5222) SDS-PAGE gel

Human PTH1R, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.

背景(Background)

Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

 

前沿进展

 
货号/价格

PTR-H5222-100ug / ¥2500

PTR-H5222-1mg (500ug X 2) / ¥16000

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PTH1R靶点信息
英文全称:Parathyroid hormone receptor
中文全称:甲状旁腺激素受体
种类:Homo sapiens
上市药物数量:15详情
临床药物数量:43详情
最高研发阶段:批准上市
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