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Human Mucin-1 / MUC-1 Protein, Fc Tag

分子别名(Synonym)

Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin

表达区间及表达系统(Source)

Human Mucin-1, Fc Tag (MU1-H5252) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Gly 167 (Accession # AAI20976).

Predicted N-terminus: Ser 33

蛋白结构(Molecular Characterization)

Online(Ser 33 - Gly 167) AAI20976

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 40.8 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human Mucin-1, Fc Tag (Cat. No. MU1-H5252) SDS-PAGE gel

Human Mucin-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.

 

前沿进展

 
货号/价格

MU1-H5252-100ug / ¥2500

MU1-H5252-1mg (500ug X 2) / ¥14400

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Mucin-1靶点信息
英文全称:Mucin-1
中文全称:黏蛋白-1
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:31详情
最高研发阶段:临床三期
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